C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: anaplastic lymphoma receptor tyrosine kinase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000171094 ALK 9606 - 2:29192774-29921566 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000389048 ALK-001 29192774-29921566 protein_coding
  ENST00000431873 ALK-201 29192777-29224730 protein_coding
  ENST00000453137 ALK-002 29220870-29223394 protein_coding
  ENST00000498037 ALK-003 29286410-29319211 processed_transcript
  ENST00000618119 ALK-202 29192777-29717700 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLungOvaryTestisENST00000389048ENST00000431873ENST00000453137ENST00000618119
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Lung Ovary Testis
ENST00000389048 N/A N/A N/A 0.464±0.00 0.037±0.00 0.097±0.05 N/A N/A N/A N/A N/A
ENST00000431873 0.145±0.00 0.032±0.00 0.295±0.00 N/A 0.082±0.00 0.156±0.00 0.068±0.04 0.024±0.00 0.051±0.00 0.048±0.01 N/A
ENST00000453137 N/A N/A N/A N/A N/A N/A N/A 0.103±0.00 N/A 0.116±0.00 N/A
ENST00000618119 N/A N/A 0.019±0.00 0.334±0.00 N/A N/A N/A N/A N/A 0.109±0.00 0.638±0.29

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00013T CIL_00013T_0001 CGP 2:29097705-29921566
CIL_0000VI CIL_0000VI_0001 CGP 2:29192774-30160533

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000187 TAS activation of MAPK activity
GO:0004672 IEA protein kinase activity
GO:0004704 TAS NF-kappaB-inducing kinase activity
GO:0004713 IDA:IEA protein tyrosine kinase activity
GO:0004714 TAS transmembrane receptor protein tyrosine kinase activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005887 TAS integral component of plasma membrane
GO:0006468 IEA protein phosphorylation
GO:0007165 TAS signal transduction
GO:0007169 IEA transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007399 IEA nervous system development
GO:0008283 TAS cell proliferation
GO:0016020 IEA membrane
GO:0016310 TAS phosphorylation
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0038061 TAS NIK/NF-kappaB signaling
GO:0042981 TAS regulation of apoptotic process
GO:0043234 IDA protein complex
GO:0046777 TAS protein autophosphorylation
GO:0048666 TAS neuron development
GO:0051092 TAS positive regulation of NF-kappaB transcription factor activity
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000095833 alk anaplastic lymphoma kinase (Ki-1) protein_coding Danio_rerio
ENSMUSG00000055471 Alk anaplastic lymphoma kinase protein_coding Mus_musculus

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