C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: DNA-damage-inducible transcript 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000175197 DDIT3 9606 - 12:57516588-57520517 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000346473 DDIT3-001 57516593-57520517 protein_coding
  ENST00000547303 DDIT3-006 57516588-57520492 protein_coding
  ENST00000547526 DDIT3-004 57516953-57520511 protein_coding
  ENST00000551116 DDIT3-002 57516589-57520517 protein_coding
  ENST00000552740 DDIT3-005 57516809-57520511 protein_coding
  ENST00000618206 DDIT3-201 57516595-57520511 protein_coding
  ENST00000623876 DDIT3-003 57516593-57517743 TEC

Homo sapiens EnsemblGRCh38

Genome
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Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBrainBreastColonKidneyLiverLungOvaryTestisENST00000547303ENST00000618206
Transcript ID Adipose Brain Breast Colon Kidney Liver Lung Ovary Testis
ENST00000547303 20.057±0.00 N/A N/A 14.882±0.00 3.103±0.00 N/A 37.090±0.00 N/A N/A
ENST00000618206 N/A 45.805±0.00 23.897±0.00 19.375±0.00 41.765±0.00 4.509±0.00 35.995±0.00 39.639±12.45 60.994±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001955 IEA blood vessel maturation
GO:0003677 IDA DNA binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0003714 TAS transcription corepressor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005770 IEA late endosome
GO:0006355 IMP:IEA regulation of transcription, DNA-templated
GO:0006915 IEA apoptotic process
GO:0006974 TAS cellular response to DNA damage stimulus
GO:0006983 IEA ER overload response
GO:0006986 IDA response to unfolded protein
GO:0006987 TAS activation of signaling protein activity involved in unfolded protein response
GO:0007050 IEA cell cycle arrest
GO:0008134 IPI transcription factor binding
GO:0016055 IEA Wnt signaling pathway
GO:0030968 TAS endoplasmic reticulum unfolded protein response
GO:0032757 IMP positive regulation of interleukin-8 production
GO:0034976 IDA response to endoplasmic reticulum stress
GO:0042594 IEA response to starvation
GO:0042789 IDA mRNA transcription from RNA polymerase II promoter
GO:0043161 IDA proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043433 IDA negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043525 IEA positive regulation of neuron apoptotic process
GO:0043565 IEA sequence-specific DNA binding
GO:0043620 TAS regulation of DNA-templated transcription in response to stress
GO:0044267 TAS cellular protein metabolic process
GO:0044324 ISS regulation of transcription involved in anterior/posterior axis specification
GO:0045454 IDA cell redox homeostasis
GO:0045662 IEA negative regulation of myoblast differentiation
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0051209 IEA release of sequestered calcium ion into cytosol
GO:0070059 IMP intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0090090 ISS negative regulation of canonical Wnt signaling pathway
GO:2000016 IDA negative regulation of determination of dorsal identity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000059836 ddit3 DNA-damage-inducible transcript 3 protein_coding Danio_rerio
ENSMUSG00000025408 Ddit3 DNA-damage inducible transcript 3 protein_coding Mus_musculus

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