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Institute of Cardiovascular Regeneration Webtool Repository

C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: polymerase (DNA directed), epsilon, catalytic subunit
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000177084 POLE 9606 - 12:132623753-132687365 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000320574 POLE-001 132623762-132687359 protein_coding
  ENST00000416953 POLE-021 132633971-132636025 retained_intron
  ENST00000434528 POLE-027 132634365-132641378 processed_transcript
  ENST00000441786 POLE-015 132626311-132635992 nonsense_mediated_decay
  ENST00000503265 POLE-016 132649353-132651407 processed_transcript
  ENST00000534922 POLE-024 132624555-132632557 retained_intron
  ENST00000535270 POLE-004 132624690-132687328 protein_coding
  ENST00000535934 POLE-010 132672627-132676498 retained_intron
  ENST00000536445 POLE-014 132649321-132660913 retained_intron
  ENST00000537064 POLE-002 132624263-132687347 nonsense_mediated_decay
  ENST00000538196 POLE-026 132625298-132632416 processed_transcript
  ENST00000539215 POLE-012 132672281-132673641 processed_transcript
  ENST00000539357 POLE-009 132681028-132687365 retained_intron
  ENST00000539618 POLE-008 132680531-132681279 retained_intron
  ENST00000540987 POLE-017 132648546-132649365 retained_intron
  ENST00000541213 POLE-020 132632448-132639169 retained_intron
  ENST00000541627 POLE-007 132623753-132625951 retained_intron
  ENST00000542362 POLE-019 132641374-132642206 retained_intron
  ENST00000544414 POLE-022 132632508-132635985 retained_intron
  ENST00000544692 POLE-003 132624706-132634168 retained_intron
  ENST00000544870 POLE-025 132626267-132636000 nonsense_mediated_decay
  ENST00000545015 POLE-013 132672544-132673233 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000320574ENST00000441786ENST00000535270ENST00000535934ENST00000537064ENST00000541627ENST00000544692
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000320574 2.632±0.00 2.556±0.00 N/A 0.490±0.00 2.473±0.00 1.413±0.11 0.072±0.00 1.742±0.19 1.421±0.00 0.848±0.39 1.566±0.00 4.534±0.66 4.406±0.90 13.062±5.19
ENST00000441786 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.169±0.00 N/A N/A N/A
ENST00000535270 N/A N/A N/A 0.235±0.00 N/A 0.851±0.00 N/A 1.126±0.00 0.481±0.00 N/A N/A 1.427±0.00 N/A N/A
ENST00000535934 N/A N/A N/A N/A N/A N/A 0.392±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000537064 N/A N/A N/A 0.191±0.00 N/A N/A N/A N/A N/A N/A 0.191±0.00 N/A N/A N/A
ENST00000541627 N/A 4.236±0.00 N/A N/A 2.289±0.00 2.481±0.00 N/A 2.028±0.00 1.592±0.00 1.764±0.00 N/A 6.602±1.15 N/A 9.092±0.00
ENST00000544692 N/A N/A 0.593±0.00 0.362±0.17 N/A N/A N/A N/A N/A N/A 0.860±0.00 N/A N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000082 IMP G1/S transition of mitotic cell cycle
GO:0000166 IEA nucleotide binding
GO:0000278 TAS mitotic cell cycle
GO:0000722 TAS telomere maintenance via recombination
GO:0000723 TAS telomere maintenance
GO:0000731 IMP DNA synthesis involved in DNA repair
GO:0001701 IEA in utero embryonic development
GO:0003676 IEA nucleic acid binding
GO:0003677 IDA:IEA DNA binding
GO:0003682 IDA chromatin binding
GO:0003887 IMP:IEA DNA-directed DNA polymerase activity
GO:0005634 IDA:IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005886 IDA plasma membrane
GO:0006260 IMP:IEA DNA replication
GO:0006270 TAS DNA replication initiation
GO:0006281 TAS DNA repair
GO:0006283 TAS transcription-coupled nucleotide-excision repair
GO:0006287 IDA base-excision repair, gap-filling
GO:0006289 TAS nucleotide-excision repair
GO:0006297 IMP nucleotide-excision repair, DNA gap filling
GO:0008270 IEA zinc ion binding
GO:0008622 IDA epsilon DNA polymerase complex
GO:0032201 TAS telomere maintenance via semi-conservative replication
GO:0051539 IEA 4 iron, 4 sulfur cluster binding
GO:0071897 IEA DNA biosynthetic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000058533 pole polymerase (DNA directed), epsilon protein_coding Danio_rerio
ENSMUSG00000007080 Pole polymerase (DNA directed), epsilon protein_coding Mus_musculus

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