C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: tyrosine hydroxylase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000180176 TH 9606 - 11:2163929-2171877 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000324155 TH-006 2165294-2171805 nonsense_mediated_decay
  ENST00000333684 TH-201 2163930-2171795 protein_coding
  ENST00000352909 TH-001 2163929-2171877 protein_coding
  ENST00000381168 TH-007 2166007-2171805 nonsense_mediated_decay
  ENST00000381175 TH-003 2163929-2171805 protein_coding
  ENST00000381178 TH-002 2163929-2171805 protein_coding
  ENST00000412076 TH-005 2165679-2168106 protein_coding
  ENST00000416223 TH-004 2165679-2168106 nonsense_mediated_decay
  ENST00000461172 TH-010 2165853-2166774 retained_intron
  ENST00000469226 TH-009 2166894-2168726 retained_intron
  ENST00000479437 TH-008 2165672-2167276 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBrainBreastColonKidneyLiverLungOvaryPlacentaTestisENST00000333684ENST00000352909ENST00000381168ENST00000381175ENST00000412076ENST00000416223ENST00000469226
Transcript ID Adrenal Brain Breast Colon Kidney Liver Lung Ovary Placenta Testis
ENST00000333684 0.052±0.00 0.140±0.02 N/A 0.024±0.00 N/A N/A N/A 0.614±0.00 0.139±0.00 N/A
ENST00000352909 N/A N/A N/A N/A N/A N/A N/A N/A 0.167±0.00 N/A
ENST00000381168 N/A N/A N/A N/A N/A 0.039±0.00 N/A N/A N/A N/A
ENST00000381175 N/A 0.173±0.00 N/A N/A 0.116±0.00 N/A N/A N/A 0.096±0.00 N/A
ENST00000412076 0.076±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 1.726±0.00
ENST00000416223 N/A N/A 0.188±0.00 N/A 0.170±0.00 N/A 0.450±0.00 6.597±6.06 1.954±0.00 0.450±0.00
ENST00000469226 N/A N/A N/A N/A 0.924±0.00 N/A N/A 0.511±0.00 N/A 0.099±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008MR CIL_0008MR_0001 VISTA 11:1663842-2266142
CIL_0007RG CIL_0007RG_0001 VISTA 11:1668349-2271510
CIL_00097V CIL_00097V_0001 VISTA 11:1688064-2293510
CIL_0009BT CIL_0009BT_0001 VISTA 11:2074187-2675527
CIL_0008VI CIL_0008VI_0001 VISTA 11:2150916-2751083
CIL_00048H CIL_00048H_0001 CGP 11:2163929-2270952

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001666 IDA response to hypoxia
GO:0001963 ISS synaptic transmission, dopaminergic
GO:0001975 IEA response to amphetamine
GO:0003007 NAS heart morphogenesis
GO:0004497 IEA monooxygenase activity
GO:0004511 IEA tyrosine 3-monooxygenase activity
GO:0005515 IPI protein binding
GO:0005634 ISS nucleus
GO:0005737 IDA cytoplasm
GO:0005739 IEA mitochondrion
GO:0005790 IDA smooth endoplasmic reticulum
GO:0005829 TAS cytosol
GO:0006585 NAS dopamine biosynthetic process from tyrosine
GO:0006631 IEA fatty acid metabolic process
GO:0006665 IEA sphingolipid metabolic process
GO:0007507 ISS heart development
GO:0007601 ISS visual perception
GO:0007605 IEA sensory perception of sound
GO:0007612 ISS learning
GO:0007613 ISS memory
GO:0007617 IEA mating behavior
GO:0007626 ISS locomotory behavior
GO:0008016 ISS regulation of heart contraction
GO:0008021 IEA synaptic vesicle
GO:0008198 IEA ferrous iron binding
GO:0008199 IEA ferric iron binding
GO:0009414 IEA response to water deprivation
GO:0009416 IEA response to light stimulus
GO:0009635 IEA response to herbicide
GO:0009651 IEA response to salt stress
GO:0009653 TAS anatomical structure morphogenesis
GO:0009887 ISS organ morphogenesis
GO:0009898 IDA cytoplasmic side of plasma membrane
GO:0010038 IEA response to metal ion
GO:0010043 IEA response to zinc ion
GO:0010259 IEA multicellular organismal aging
GO:0014070 IEA response to organic cyclic compound
GO:0014823 IEA response to activity
GO:0015842 IEA synaptic vesicle amine transport
GO:0016137 IEA glycoside metabolic process
GO:0016597 IEA amino acid binding
GO:0016714 IEA oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
GO:0017085 IEA response to insecticide
GO:0018963 IEA phthalate metabolic process
GO:0019825 IEA oxygen binding
GO:0019899 IPI enzyme binding
GO:0019904 IEA protein domain specific binding
GO:0021987 IEA cerebral cortex development
GO:0030424 IEA axon
GO:0030425 IEA dendrite
GO:0030659 IEA cytoplasmic vesicle membrane
GO:0031410 IDA cytoplasmic vesicle
GO:0031667 IEA response to nutrient levels
GO:0032355 IEA response to estradiol
GO:0032496 IEA response to lipopolysaccharide
GO:0033076 IEA isoquinoline alkaloid metabolic process
GO:0033162 IDA melanosome membrane
GO:0034617 IEA tetrahydrobiopterin binding
GO:0034641 TAS cellular nitrogen compound metabolic process
GO:0035094 IEA response to nicotine
GO:0035176 IEA social behavior
GO:0035240 IEA dopamine binding
GO:0035690 IEA cellular response to drug
GO:0035902 IEA response to immobilization stress
GO:0042136 IEA neurotransmitter biosynthetic process
GO:0042214 IEA terpene metabolic process
GO:0042416 IDA dopamine biosynthetic process
GO:0042418 IDA epinephrine biosynthetic process
GO:0042421 IDA norepinephrine biosynthetic process
GO:0042423 TAS catecholamine biosynthetic process
GO:0042462 ISS eye photoreceptor cell development
GO:0042493 IEA response to drug
GO:0042745 IEA circadian sleep/wake cycle
GO:0042755 IEA eating behavior
GO:0043005 IDA neuron projection
GO:0043025 IEA neuronal cell body
GO:0043195 IEA terminal bouton
GO:0043204 ISS perikaryon
GO:0043434 IEA response to peptide hormone
GO:0043473 TAS pigmentation
GO:0044281 TAS small molecule metabolic process
GO:0045471 IDA response to ethanol
GO:0045472 IEA response to ether
GO:0046684 IEA response to pyrethroid
GO:0048545 IEA response to steroid hormone
GO:0048596 ISS embryonic camera-type eye morphogenesis
GO:0050890 IEA cognition
GO:0051412 IEA response to corticosterone
GO:0051602 IEA response to electrical stimulus
GO:0052314 IEA phytoalexin metabolic process
GO:0055114 IEA oxidation-reduction process
GO:0070848 IEA response to growth factor
GO:0071287 IEA cellular response to manganese ion
GO:0071312 IEA cellular response to alkaloid
GO:0071316 IEA cellular response to nicotine
GO:0071333 IEA cellular response to glucose stimulus
GO:0071363 IEA cellular response to growth factor stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000030621 th tyrosine hydroxylase protein_coding Danio_rerio
ENSMUSG00000000214 Th tyrosine hydroxylase protein_coding Mus_musculus

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