C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: angiotensin II receptor, type 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000180772 AGTR2 9606 + X:116170722-116174972 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000371906 AGTR2-001 116170722-116174972 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBladderBreastColonHeartKidneyLiverLungOvaryTestisENST00000371906
Transcript ID Adrenal Bladder Breast Colon Heart Kidney Liver Lung Ovary Testis
ENST00000371906 0.012±0.00 0.123±0.00 0.240±0.00 0.032±0.00 0.084±0.00 0.012±0.00 0.109±0.00 1.723±0.85 0.360±0.34 0.087±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000712 CIL_000712_0001 CGP X:116170722-116461458

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001822 IEA kidney development
GO:0001974 TAS blood vessel remodeling
GO:0001991 ISS regulation of systemic arterial blood pressure by circulatory renin-angiotensin
GO:0002018 IEA renin-angiotensin regulation of aldosterone production
GO:0002033 IEA vasodilation by angiotensin involved in regulation of systemic arterial blood pressure
GO:0002035 IEA brain renin-angiotensin system
GO:0004930 IEA G-protein coupled receptor activity
GO:0004945 IPI angiotensin type II receptor activity
GO:0005515 IPI protein binding
GO:0005576 TAS extracellular region
GO:0005886 TAS plasma membrane
GO:0005887 IC integral component of plasma membrane
GO:0006883 IEA cellular sodium ion homeostasis
GO:0006954 IEA inflammatory response
GO:0007166 IDA cell surface receptor signaling pathway
GO:0007186 IC:IEA G-protein coupled receptor signaling pathway
GO:0007199 ISS G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
GO:0007263 IC nitric oxide mediated signal transduction
GO:0007420 NAS brain development
GO:0008134 IEA transcription factor binding
GO:0008217 TAS regulation of blood pressure
GO:0008284 IEA positive regulation of cell proliferation
GO:0010243 IEA response to organonitrogen compound
GO:0010459 ISS negative regulation of heart rate
GO:0010700 IEA negative regulation of norepinephrine secretion
GO:0016021 IEA integral component of membrane
GO:0017046 IEA peptide hormone binding
GO:0021695 IEA cerebellar cortex development
GO:0030308 TAS negative regulation of cell growth
GO:0032304 IEA negative regulation of icosanoid secretion
GO:0032516 IDA positive regulation of phosphoprotein phosphatase activity
GO:0035556 ISS intracellular signal transduction
GO:0035566 IEA regulation of metanephros size
GO:0035640 IEA exploration behavior
GO:0035815 IEA positive regulation of renal sodium excretion
GO:0035932 IEA aldosterone secretion
GO:0038166 IEA angiotensin-activated signaling pathway
GO:0042416 IEA dopamine biosynthetic process
GO:0042990 IEA regulation of transcription factor import into nucleus
GO:0043537 NAS negative regulation of blood vessel endothelial cell migration
GO:0045429 IC positive regulation of nitric oxide biosynthetic process
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0045909 IDA positive regulation of vasodilation
GO:0048019 TAS receptor antagonist activity
GO:0048147 IEA negative regulation of fibroblast proliferation
GO:0048471 IEA perinuclear region of cytoplasm
GO:0050715 IEA positive regulation of cytokine secretion
GO:0051000 ISS positive regulation of nitric-oxide synthase activity
GO:0051387 IMP negative regulation of neurotrophin TRK receptor signaling pathway
GO:0060993 IEA kidney morphogenesis
GO:0061049 IEA cell growth involved in cardiac muscle cell development
GO:0071549 IEA cellular response to dexamethasone stimulus
GO:0072300 IEA positive regulation of metanephric glomerulus development
GO:0090190 IEA positive regulation of branching involved in ureteric bud morphogenesis
GO:1900116 TAS extracellular negative regulation of signal transduction
GO:2001238 IMP positive regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000035552 agtr2 angiotensin II receptor, type 2 protein_coding Danio_rerio
ENSMUSG00000068122 Agtr2 angiotensin II receptor, type 2 protein_coding Mus_musculus

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