C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: nucleophosmin (nucleolar phosphoprotein B23, numatrin)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000181163 NPM1 9606 + 5:171387116-171411137 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000296930 NPM1-001 171387648-171411137 protein_coding
  ENST00000351986 NPM1-002 171387829-171410884 protein_coding
  ENST00000393820 NPM1-003 171387851-171407125 protein_coding
  ENST00000517671 NPM1-004 171387116-171410883 protein_coding
  ENST00000518587 NPM1-008 171387885-171392963 retained_intron
  ENST00000519955 NPM1-011 171400786-171405732 retained_intron
  ENST00000521260 NPM1-009 171390094-171391777 retained_intron
  ENST00000521672 NPM1-005 171387799-171400155 protein_coding
  ENST00000521710 NPM1-010 171391083-171391749 retained_intron
  ENST00000523339 NPM1-006 171387852-171390163 retained_intron
  ENST00000523622 NPM1-007 171387881-171391369 protein_coding
  ENST00000524204 NPM1-012 171407493-171410884 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000296930ENST00000351986ENST00000393820ENST00000517671
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000296930 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 119.804±0.00 N/A N/A
ENST00000351986 61.838±0.00 90.641±0.00 32.569±0.00 33.125±1.28 49.643±4.19 85.163±41.74 23.894±5.21 22.371±0.00 48.107±24.58 55.839±3.08 18.377±1.58 74.951±8.05 34.886±0.00 86.646±0.00
ENST00000393820 N/A N/A N/A N/A N/A N/A N/A 10.311±0.00 6.691±0.00 N/A N/A N/A 21.396±0.00 N/A
ENST00000517671 78.916±0.00 91.377±0.00 33.339±0.00 44.433±2.92 55.929±0.00 83.052±56.30 41.933±0.00 55.290±17.65 59.202±23.32 80.333±23.24 41.166±33.00 226.892±188.23 273.838±156.19 233.688±131.82

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00088M CIL_00088M_0001 VISTA 5:170856489-171457417
CIL_00097F CIL_00097F_0001 VISTA 5:170900986-171503014
CIL_00092S CIL_00092S_0001 VISTA 5:171022159-171623481

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003676 IEA nucleic acid binding
GO:0003713 IDA transcription coactivator activity
GO:0003723 IDA RNA binding
GO:0004860 IDA protein kinase inhibitor activity
GO:0005515 IPI protein binding
GO:0005634 ISS nucleus
GO:0005654 IDA nucleoplasm
GO:0005730 IDA nucleolus
GO:0005737 ISS cytoplasm
GO:0005813 ISS centrosome
GO:0005829 TAS cytosol
GO:0005925 IDA focal adhesion
GO:0006281 IDA DNA repair
GO:0006334 IDA nucleosome assembly
GO:0006886 TAS intracellular protein transport
GO:0006913 TAS nucleocytoplasmic transport
GO:0006950 IMP response to stress
GO:0007098 ISS centrosome cycle
GO:0007165 NAS signal transduction
GO:0007569 ISS cell aging
GO:0008104 IDA protein localization
GO:0008285 ISS negative regulation of cell proliferation
GO:0010826 IMP negative regulation of centrosome duplication
GO:0016020 IDA membrane
GO:0016032 TAS viral process
GO:0019901 IPI protein kinase binding
GO:0030529 IDA ribonucleoprotein complex
GO:0030957 IDA Tat protein binding
GO:0031616 IDA spindle pole centrosome
GO:0032071 IDA regulation of endodeoxyribonuclease activity
GO:0034080 TAS CENP-A containing nucleosome assembly
GO:0042255 TAS ribosome assembly
GO:0042393 IDA histone binding
GO:0042803 IDA protein homodimerization activity
GO:0043023 IDA ribosomal large subunit binding
GO:0043024 IDA ribosomal small subunit binding
GO:0043066 IDA negative regulation of apoptotic process
GO:0044387 IDA negative regulation of protein kinase activity by regulation of protein phosphorylation
GO:0044822 IDA poly(A) RNA binding
GO:0045727 IDA positive regulation of translation
GO:0046599 IMP regulation of centriole replication
GO:0046982 IMP protein heterodimerization activity
GO:0051059 ISS NF-kappaB binding
GO:0051082 ISS unfolded protein binding
GO:0051092 IMP positive regulation of NF-kappaB transcription factor activity
GO:0051259 IDA protein oligomerization
GO:0060699 IDA regulation of endoribonuclease activity
GO:0060735 IDA regulation of eIF2 alpha phosphorylation by dsRNA

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000014329 npm1a nucleophosmin 1a protein_coding Danio_rerio
ENSMUSG00000057113 Npm1 nucleophosmin 1 protein_coding Mus_musculus
ENSMUSG00000090602 Gm5611 predicted gene 5611 protein_coding Mus_musculus

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