C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: topoisomerase (DNA) I, mitochondrial
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000184428 TOP1MT 9606 - 8:143304384-143359979 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000329245 TOP1MT-001 143309324-143334896 protein_coding
  ENST00000505857 TOP1MT-004 143343199-143359979 processed_transcript
  ENST00000517857 TOP1MT-012 143309356-143310503 retained_intron
  ENST00000518007 TOP1MT-021 143325522-143344984 protein_coding
  ENST00000518760 TOP1MT-020 143326290-143356046 protein_coding
  ENST00000518951 TOP1MT-007 143316000-143334863 nonsense_mediated_decay
  ENST00000519139 TOP1MT-006 143316092-143334056 protein_coding
  ENST00000519148 TOP1MT-002 143309360-143359977 protein_coding
  ENST00000519591 TOP1MT-016 143324060-143334854 protein_coding
  ENST00000519977 TOP1MT-013 143304384-143315807 protein_coding
  ENST00000520950 TOP1MT-011 143326312-143359960 protein_coding
  ENST00000521024 TOP1MT-010 143344737-143358666 processed_transcript
  ENST00000521193 TOP1MT-003 143309356-143359924 protein_coding
  ENST00000522041 TOP1MT-017 143324000-143331811 protein_coding
  ENST00000522043 TOP1MT-015 143329387-143334866 protein_coding
  ENST00000522121 TOP1MT-018 143325355-143329433 nonsense_mediated_decay
  ENST00000523417 TOP1MT-019 143325425-143334844 nonsense_mediated_decay
  ENST00000523676 TOP1MT-005 143309377-143334795 protein_coding
  ENST00000524092 TOP1MT-014 143332503-143334821 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000329245ENST00000505857ENST00000517857ENST00000518007ENST00000518951ENST00000519148ENST00000519591ENST00000519977ENST00000521193ENST00000522041ENST00000522043ENST00000523417ENST00000523676
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000329245 N/A 6.604±0.00 0.527±0.00 N/A N/A 2.300±0.98 0.222±0.16 0.622±0.25 1.692±0.00 2.980±0.00 1.871±0.00 22.191±13.05 7.663±1.41 N/A
ENST00000505857 N/A N/A N/A N/A N/A N/A 0.080±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000517857 N/A N/A N/A N/A 1.106±0.00 N/A N/A N/A N/A 0.822±0.00 N/A N/A N/A N/A
ENST00000518007 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.007±0.00 N/A N/A N/A
ENST00000518951 3.765±0.00 N/A N/A N/A N/A N/A 0.054±0.00 1.400±0.00 N/A N/A N/A 15.056±0.00 N/A 12.612±0.00
ENST00000519148 10.832±0.00 8.960±0.00 0.221±0.00 2.131±0.00 9.563±0.00 8.923±0.00 0.630±0.00 2.134±1.89 6.571±0.00 2.545±0.00 0.894±0.00 19.304±0.00 N/A 22.275±0.00
ENST00000519591 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.700±0.00 N/A N/A N/A N/A
ENST00000519977 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.588±0.00 N/A N/A N/A
ENST00000521193 N/A N/A N/A 0.745±0.00 N/A N/A N/A N/A N/A 0.331±0.00 N/A N/A N/A 18.759±6.42
ENST00000522041 N/A N/A N/A N/A 0.714±0.00 N/A 0.292±0.00 N/A N/A 0.506±0.00 N/A N/A N/A N/A
ENST00000522043 N/A N/A 0.820±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000523417 N/A N/A N/A N/A N/A N/A N/A N/A 1.270±0.00 N/A N/A N/A N/A N/A
ENST00000523676 N/A N/A N/A 2.246±0.00 N/A N/A 0.388±0.00 N/A N/A 1.708±0.00 1.556±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008C2 CIL_0008C2_0001 VISTA 8:143231340-143832399
CIL_0001NH CIL_0001NH_0001 CGP 8:143304384-143384220

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003677 IEA DNA binding
GO:0003917 IEA:IBA DNA topoisomerase type I activity
GO:0003918 IEA DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005634 IDA nucleus
GO:0005694 IEA chromosome
GO:0005739 IDA mitochondrion
GO:0006200 IEA ATP catabolic process
GO:0006260 IBA DNA replication
GO:0006265 IEA:IBA DNA topological change
GO:0042645 IDA mitochondrial nucleoid

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000055959 CABZ01090980.1 Uncharacterized protein protein_coding Danio_rerio
ENSMUSG00000000934 Top1mt DNA topoisomerase 1, mitochondrial protein_coding Mus_musculus

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