C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: aldo-keto reductase family 1, member C1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000187134 AKR1C1 9606 + 10:4963253-5107522 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000380859 AKR1C1-004 4963789-4969941 protein_coding
  ENST00000380872 AKR1C1-001 4963253-4983283 protein_coding
  ENST00000434459 AKR1C1-201 4963445-5107522 protein_coding
  ENST00000442997 AKR1C1-003 4963449-4972747 protein_coding
  ENST00000476100 AKR1C1-005 4965491-4967048 processed_transcript
  ENST00000477661 AKR1C1-002 4963253-4977950 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBladderBrainBreastHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000380859ENST00000380872ENST00000434459ENST00000442997ENST00000477661
Transcript ID Adrenal Bladder Brain Breast Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000380859 N/A N/A N/A N/A N/A N/A 7.765±0.00 N/A N/A N/A N/A N/A
ENST00000380872 0.578±0.00 N/A 0.140±0.01 4.026±3.68 0.462±0.00 3.952±0.00 0.844±0.00 N/A N/A 0.313±0.00 0.089±0.00 0.768±0.44
ENST00000434459 N/A 3.675±0.00 0.862±0.00 3.283±0.00 1.271±0.00 47.498±0.00 7.854±0.00 4.036±0.00 2.606±0.00 N/A 0.531±0.00 N/A
ENST00000442997 12.020±0.00 N/A 1.880±0.00 166.414±0.00 6.855±0.00 N/A 143.348±0.00 19.042±0.00 2.475±0.00 8.256±0.00 N/A 11.155±7.35
ENST00000477661 1.397±0.00 N/A 0.697±0.00 1.184±0.00 N/A 17.982±0.00 N/A 1.810±0.00 0.452±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002HN CIL_0002HN_0001 CGP 10:4922564-5135226
CIL_0002HN CIL_0002HN_0002 CGP 10:4963253-5107686

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001523 TAS retinoid metabolic process
GO:0004032 IDA alditol:NADP+ 1-oxidoreductase activity
GO:0004033 TAS aldo-keto reductase (NADP) activity
GO:0005829 IDA cytosol
GO:0006805 NAS xenobiotic metabolic process
GO:0007586 IDA digestion
GO:0007603 TAS phototransduction, visible light
GO:0008206 IDA bile acid metabolic process
GO:0015721 TAS bile acid and bile salt transport
GO:0016491 IEA oxidoreductase activity
GO:0016655 IDA oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO:0018636 IDA phenanthrene 9,10-monooxygenase activity
GO:0030299 TAS intestinal cholesterol absorption
GO:0030855 IDA epithelial cell differentiation
GO:0031406 IDA carboxylic acid binding
GO:0032052 IDA bile acid binding
GO:0042448 IDA progesterone metabolic process
GO:0042574 IDA retinal metabolic process
GO:0042632 TAS cholesterol homeostasis
GO:0044597 IMP daunorubicin metabolic process
GO:0044598 IMP doxorubicin metabolic process
GO:0046683 IEP response to organophosphorus
GO:0047006 IEA 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity
GO:0047042 IDA androsterone dehydrogenase (B-specific) activity
GO:0047086 IDA ketosteroid monooxygenase activity
GO:0047115 IDA trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
GO:0047718 IEA indanol dehydrogenase activity
GO:0051260 IDA protein homooligomerization
GO:0055114 IEA oxidation-reduction process
GO:0070062 IDA extracellular vesicular exosome
GO:0071395 IDA cellular response to jasmonic acid stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000021207 Akr1c21 aldo-keto reductase family 1, member C21 protein_coding Mus_musculus
ENSMUSG00000021210 Akr1c6 aldo-keto reductase family 1, member C6 protein_coding Mus_musculus
ENSMUSG00000021214 Akr1c18 aldo-keto reductase family 1, member C18 protein_coding Mus_musculus
ENSMUSG00000025955 Akr1cl aldo-keto reductase family 1, member C-like protein_coding Mus_musculus
ENSMUSG00000033715 Akr1c14 aldo-keto reductase family 1, member C14 protein_coding Mus_musculus
ENSMUSG00000054757 Akr1c20 aldo-keto reductase family 1, member C20 protein_coding Mus_musculus

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