C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: major histocompatibility complex, class II, DQ alpha 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000196735 HLA-DQA1 9606 + 6:32628179-32647062 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000343139 HLA-DQA1-001 32637357-32643652 protein_coding
  ENST00000374949 HLA-DQA1-009 32637420-32643017 protein_coding
  ENST00000395363 HLA-DQA1-004 32637401-32643652 protein_coding
  ENST00000422863 HLA-DQA1-010 32628179-32637531 protein_coding
  ENST00000460633 HLA-DQA1-003 32637431-32647062 retained_intron
  ENST00000482745 HLA-DQA1-002 32637427-32643272 nonsense_mediated_decay
  ENST00000496318 HLA-DQA1-007 32637406-32642981 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000343139ENST00000374949ENST00000395363ENST00000460633ENST00000496318
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000343139 2.969±0.00 9.832±0.00 1.115±0.00 0.505±0.39 5.076±1.60 1.208±0.94 1.561±0.79 2.945±1.18 0.572±0.00 45.296±27.78 2.644±0.00 2.431±1.90 10.654±4.99 2.300±0.00
ENST00000374949 N/A 16.196±0.00 N/A N/A N/A 0.262±0.00 N/A 2.677±0.00 0.304±0.00 N/A N/A N/A N/A 1.049±0.00
ENST00000395363 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.424±0.00
ENST00000460633 0.124±0.00 3.775±0.00 0.331±0.00 N/A 1.315±0.00 N/A 0.168±0.00 0.171±0.02 0.139±0.00 1.649±0.00 0.072±0.00 0.062±0.01 0.111±0.00 0.096±0.08
ENST00000496318 5.373±0.00 19.121±0.00 2.867±0.00 2.378±1.84 17.621±8.89 0.437±0.00 3.511±2.49 7.671±3.12 2.044±1.40 63.251±14.60 3.481±0.95 6.284±3.57 5.665±2.18 3.060±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002XS CIL_0002XS_0008 CGP 6:32552990-32647062
CIL_0001PL CIL_0001PL_0006 CGP 6:32628179-32668383

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000139 TAS Golgi membrane
GO:0002504 IEA antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO:0005515 IEA protein binding
GO:0005764 IEA lysosome
GO:0005765 TAS lysosomal membrane
GO:0005768 IEA endosome
GO:0005886 TAS plasma membrane
GO:0005887 NAS integral component of plasma membrane
GO:0006955 NAS:IEA immune response
GO:0009897 IEA external side of plasma membrane
GO:0012507 TAS ER to Golgi transport vesicle membrane
GO:0016020 IDA:IEA membrane
GO:0016021 IEA integral component of membrane
GO:0019221 TAS cytokine-mediated signaling pathway
GO:0019882 IEA antigen processing and presentation
GO:0019886 TAS antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0030658 TAS transport vesicle membrane
GO:0030666 TAS endocytic vesicle membrane
GO:0030669 TAS clathrin-coated endocytic vesicle membrane
GO:0031295 TAS T cell costimulation
GO:0032395 TAS MHC class II receptor activity
GO:0032588 TAS trans-Golgi network membrane
GO:0034341 IEA response to interferon-gamma
GO:0042605 ISS peptide antigen binding
GO:0042613 ISS:IEA MHC class II protein complex
GO:0045582 IEA positive regulation of T cell differentiation
GO:0048002 IEA antigen processing and presentation of peptide antigen
GO:0050852 TAS T cell receptor signaling pathway
GO:0060333 TAS interferon-gamma-mediated signaling pathway
GO:0071556 TAS integral component of lumenal side of endoplasmic reticulum membrane

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000001832 si:ch1073-403i13.1 si:ch1073-403i13.1 protein_coding Danio_rerio
ENSDARG00000020286 zgc:123107 zgc:123107 protein_coding Danio_rerio
ENSDARG00000031745 si:busm1-266f07.2 si:busm1-266f07.2 protein_coding Danio_rerio
ENSDARG00000053739 si:busm1-160c18.1 si:busm1-160c18.1 protein_coding Danio_rerio
ENSDARG00000055441 si:busm1-48c11.3 si:busm1-48c11.3 protein_coding Danio_rerio
ENSDARG00000070206 si:zfos-2070c2.1 si:zfos-2070c2.1 protein_coding Danio_rerio
ENSDARG00000074816 si:zfos-367g9.1 si:zfos-367g9.1 protein_coding Danio_rerio
ENSDARG00000075932 si:ch73-211l2.3 si:ch73-211l2.3 protein_coding Danio_rerio
ENSDARG00000079593 si:busm1-228j01.5 si:busm1-228j01.5 protein_coding Danio_rerio
ENSDARG00000086294 CU914776.1 Uncharacterized protein protein_coding Danio_rerio
ENSMUSG00000036594 H2-Aa histocompatibility 2, class II antigen A, alpha protein_coding Mus_musculus

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