C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: dishevelled-binding antagonist of beta-catenin 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000197380 DACT3 9606 - 19:46647612-46661138 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000300875 DACT3-002 46647612-46654657 protein_coding
  ENST00000391916 DACT3-001 46647612-46661138 protein_coding
  ENST00000410105 DACT3-003 46650148-46661138 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000300875ENST00000391916ENST00000410105
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000300875 N/A N/A 1.659±0.00 N/A N/A N/A 2.918±0.00 0.133±0.00 2.106±1.69 0.210±0.00 1.496±0.00 3.715±2.72 2.045±0.78 5.068±0.00
ENST00000391916 5.002±0.00 21.624±0.00 0.239±0.00 43.024±0.00 3.128±0.88 19.503±16.54 5.663±4.70 6.398±0.00 9.144±0.00 12.368±11.18 1.487±0.17 16.328±22.16 1.238±0.28 12.085±10.96
ENST00000410105 N/A N/A N/A N/A 0.380±0.00 N/A N/A N/A 0.135±0.00 0.122±0.00 N/A 0.113±0.00 N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005080 ISS protein kinase C binding
GO:0005515 IEA protein binding
GO:0005737 IEA cytoplasm
GO:0010719 IEA negative regulation of epithelial to mesenchymal transition
GO:0016055 IEA Wnt signaling pathway
GO:0030178 IDA negative regulation of Wnt signaling pathway
GO:0030308 IDA negative regulation of cell growth
GO:0035414 IDA negative regulation of catenin import into nucleus
GO:0042802 IEA identical protein binding
GO:0051018 ISS protein kinase A binding
GO:0070097 ISS delta-catenin binding
GO:0090090 IEA negative regulation of canonical Wnt signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000087910 DACT3 (1 of 2) dishevelled-binding antagonist of beta-catenin 3 protein_coding Danio_rerio
ENSDARG00000088409 DACT3 (2 of 2) dishevelled-binding antagonist of beta-catenin 3 protein_coding Danio_rerio
ENSMUSG00000078794 Dact3 dapper homolog 3, antagonist of beta-catenin (xenopus) protein_coding Mus_musculus

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