C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: tousled-like kinase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000198586 TLK1 9606 - 2:170990823-171231314 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000359766 TLK1-004 170992154-171160495 nonsense_mediated_decay
  ENST00000360843 TLK1-002 170990823-171160833 protein_coding
  ENST00000409443 TLK1-003 170996724-171160900 nonsense_mediated_decay
  ENST00000413010 TLK1-011 171028345-171160564 processed_transcript
  ENST00000431350 TLK1-001 170990823-171160833 protein_coding
  ENST00000434911 TLK1-005 170993727-171066973 protein_coding
  ENST00000453628 TLK1-010 171053782-171066936 protein_coding
  ENST00000466220 TLK1-007 171117752-171159827 processed_transcript
  ENST00000470340 TLK1-008 171082781-171155770 processed_transcript
  ENST00000478683 TLK1-006 171045231-171055129 retained_intron
  ENST00000486857 TLK1-009 171053717-171091810 processed_transcript
  ENST00000521943 TLK1-012 170993507-171231314 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000359766ENST00000360843ENST00000409443ENST00000431350ENST00000434911ENST00000521943
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000359766 6.054±0.00 2.633±0.00 N/A 1.956±0.33 1.968±0.68 3.891±1.39 0.620±0.00 3.434±2.22 2.155±0.06 3.237±0.00 2.429±0.00 3.780±2.07 3.057±1.53 6.776±3.56
ENST00000360843 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.519±0.00 N/A N/A
ENST00000409443 N/A N/A N/A N/A N/A 3.088±0.00 0.348±0.00 1.980±0.00 N/A 2.091±0.00 N/A N/A N/A N/A
ENST00000431350 2.318±0.00 1.225±0.00 2.243±0.00 1.995±0.35 1.085±0.00 1.078±0.00 0.469±0.16 1.108±0.00 0.756±0.00 2.655±0.00 0.609±0.00 2.511±0.99 3.093±1.69 1.831±0.00
ENST00000434911 N/A N/A 7.377±0.00 6.045±0.00 10.562±0.00 8.274±0.00 1.185±0.00 6.771±0.00 6.395±0.00 8.379±0.00 0.613±0.00 8.983±0.00 N/A N/A
ENST00000521943 N/A N/A N/A 1.653±0.00 N/A N/A N/A N/A 3.950±0.00 N/A N/A 7.608±0.00 11.915±0.00 17.422±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003IO CIL_0003IO_0002 CGP 2:170928464-171231314
CIL_0004S9 CIL_0004S9_0001 CGP 2:170990823-171434802

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001672 IDA regulation of chromatin assembly or disassembly
GO:0004672 IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0006468 IEA protein phosphorylation
GO:0006886 IDA intracellular protein transport
GO:0006974 IEA cellular response to DNA damage stimulus
GO:0007049 IEA cell cycle
GO:0016301 IEA kinase activity
GO:0016310 IEA phosphorylation
GO:0016568 IEA chromatin modification
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0035556 IDA intracellular signal transduction

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000042467 tlk1a tousled-like kinase 1a protein_coding Danio_rerio
ENSDARG00000059190 tlk1b tousled-like kinase 1b protein_coding Danio_rerio
ENSMUSG00000041997 Tlk1 tousled-like kinase 1 protein_coding Mus_musculus

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