C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: bone morphogenetic protein receptor, type II (serine/threonine kinase)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000204217 BMPR2 9606 + 2:202376936-202567751 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000374574 BMPR2-002 202377434-202567751 protein_coding
  ENST00000374580 BMPR2-001 202376936-202567751 protein_coding
  ENST00000479069 BMPR2-003 202464826-202475139 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000374574ENST00000374580
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000374574 N/A 1.049±0.00 N/A N/A 0.898±0.00 N/A N/A N/A 0.204±0.00 N/A N/A N/A N/A N/A
ENST00000374580 10.523±0.00 5.571±0.00 5.107±0.00 11.048±0.96 7.616±0.90 5.494±3.01 6.538±2.36 5.478±1.54 4.881±3.47 19.452±2.17 3.106±1.18 5.494±0.82 6.680±1.42 4.186±3.56

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00020S CIL_00020S_0001 CGP 2:202265716-202567751
CIL_0000JN CIL_0000JN_0003 CGP 2:202376936-202769757

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001707 ISS mesoderm formation
GO:0001938 IMP positive regulation of endothelial cell proliferation
GO:0001946 ISS lymphangiogenesis
GO:0001974 ISS blood vessel remodeling
GO:0002063 IMP chondrocyte development
GO:0003085 IMP negative regulation of systemic arterial blood pressure
GO:0004672 IEA protein kinase activity
GO:0004675 IEA transmembrane receptor protein serine/threonine kinase activity
GO:0004702 IEA receptor signaling protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005024 IEA transforming growth factor beta-activated receptor activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005615 IDA extracellular space
GO:0005737 IEA cytoplasm
GO:0005886 IDA plasma membrane
GO:0005887 IDA integral component of plasma membrane
GO:0005901 IMP caveola
GO:0006366 IMP transcription from RNA polymerase II promoter
GO:0006468 IEA protein phosphorylation
GO:0007178 IDA transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007420 IEA brain development
GO:0009267 IEP cellular response to starvation
GO:0009925 IEA basal plasma membrane
GO:0009952 ISS anterior/posterior pattern specification
GO:0009986 IEA cell surface
GO:0010595 IMP positive regulation of endothelial cell migration
GO:0010634 IDA positive regulation of epithelial cell migration
GO:0010862 IMP positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0014916 ISS regulation of lung blood pressure
GO:0016020 IEA membrane
GO:0016324 IEA apical plasma membrane
GO:0016362 TAS activin receptor activity, type II
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0019838 IEA growth factor binding
GO:0023014 IEA signal transduction by phosphorylation
GO:0030308 IDA negative regulation of cell growth
GO:0030425 IEA dendrite
GO:0030501 IMP positive regulation of bone mineralization
GO:0030509 ISS BMP signaling pathway
GO:0030513 IMP positive regulation of BMP signaling pathway
GO:0032924 TAS activin receptor signaling pathway
GO:0042127 IMP regulation of cell proliferation
GO:0043025 IEA neuronal cell body
GO:0044214 TAS fully spanning plasma membrane
GO:0045669 IMP positive regulation of osteoblast differentiation
GO:0045906 ISS negative regulation of vasoconstriction
GO:0046872 IEA metal ion binding
GO:0048010 ISS vascular endothelial growth factor receptor signaling pathway
GO:0048286 ISS lung alveolus development
GO:0048842 IEA positive regulation of axon extension involved in axon guidance
GO:0060041 IEA retina development in camera-type eye
GO:0060173 IEA limb development
GO:0060836 ISS lymphatic endothelial cell differentiation
GO:0060840 ISS artery development
GO:0060841 ISS venous blood vessel development
GO:0061298 ISS retina vasculature development in camera-type eye
GO:1902731 IMP negative regulation of chondrocyte proliferation
GO:2000279 IMP negative regulation of DNA biosynthetic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000011941 bmpr2a bone morphogenetic protein receptor, type II a (serine/threonine kinase) protein_coding Danio_rerio
ENSDARG00000020057 bmpr2b bone morphogenetic protein receptor, type II b (serine/threonine kinase) protein_coding Danio_rerio
ENSMUSG00000067336 Bmpr2 bone morphogenetic protein receptor, type II (serine/threonine kinase) protein_coding Mus_musculus

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