C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: linker for activation of T cells
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000213658 LAT 9606 + 16:28984826-28990783 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000360872 LAT-001 28985340-28990773 protein_coding
  ENST00000395456 LAT-004 28985096-28990773 protein_coding
  ENST00000395461 LAT-002 28984826-28990783 protein_coding
  ENST00000454369 LAT-007 28985123-28990449 protein_coding
  ENST00000562472 LAT-008 28985064-28986232 retained_intron
  ENST00000562701 LAT-006 28985418-28990012 nonsense_mediated_decay
  ENST00000563964 LAT-009 28985066-28986843 processed_transcript
  ENST00000564277 LAT-012 28985054-28990019 protein_coding
  ENST00000564447 LAT-015 28987566-28990454 retained_intron
  ENST00000566177 LAT-005 28985418-28990012 protein_coding
  ENST00000566270 LAT-003 28985049-28986302 retained_intron
  ENST00000566415 LAT-013 28989577-28990455 retained_intron
  ENST00000568440 LAT-010 28986099-28986697 retained_intron
  ENST00000568899 LAT-014 28985842-28990296 retained_intron
  ENST00000570232 LAT-011 28986212-28990513 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBrainBreastColonLiverLungOvaryENST00000454369ENST00000562472ENST00000563964ENST00000564447ENST00000566177ENST00000568899
Transcript ID Adrenal Brain Breast Colon Liver Lung Ovary
ENST00000454369 25.212±0.00 N/A N/A N/A N/A 10.138±0.00 12.115±0.00
ENST00000562472 N/A N/A N/A N/A 0.504±0.00 N/A N/A
ENST00000563964 N/A N/A 0.628±0.00 N/A N/A N/A N/A
ENST00000564447 N/A 0.660±0.00 N/A N/A N/A N/A N/A
ENST00000566177 N/A N/A N/A 0.950±0.00 N/A N/A N/A
ENST00000568899 N/A N/A N/A N/A N/A N/A 8.962±7.36

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001772 IDA immunological synapse
GO:0002260 IEA lymphocyte homeostasis
GO:0005070 IDA SH3/SH2 adaptor activity
GO:0005515 IPI protein binding
GO:0005886 TAS plasma membrane
GO:0005911 IEA cell-cell junction
GO:0006954 IEA inflammatory response
GO:0006955 IDA immune response
GO:0007165 IEA signal transduction
GO:0007229 IDA integrin-mediated signaling pathway
GO:0007265 IMP Ras protein signal transduction
GO:0007596 TAS blood coagulation
GO:0008180 ISS COP9 signalosome
GO:0009967 IDA positive regulation of signal transduction
GO:0010467 IEA gene expression
GO:0016020 IEA membrane
GO:0016021 IDA integral component of membrane
GO:0019722 IMP calcium-mediated signaling
GO:0019901 IPI protein kinase binding
GO:0030168 TAS platelet activation
GO:0035556 IDA intracellular signal transduction
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0042110 TAS T cell activation
GO:0042629 IEA mast cell granule
GO:0043303 IEA mast cell degranulation
GO:0045087 TAS innate immune response
GO:0045121 TAS membrane raft
GO:0048872 IEA homeostasis of number of cells
GO:0050852 TAS T cell receptor signaling pathway
GO:0050863 IMP regulation of T cell activation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000030742 Lat linker for activation of T cells protein_coding Mus_musculus

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