C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: protein phosphatase 2, regulatory subunit B, alpha
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000221914 PPP2R2A 9606 + 8:26291491-26372680 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000315985 PPP2R2A-002 26293216-26370886 protein_coding
  ENST00000380737 PPP2R2A-001 26291491-26372680 protein_coding
  ENST00000517754 PPP2R2A-003 26361090-26371129 retained_intron
  ENST00000518208 PPP2R2A-024 26365098-26370314 retained_intron
  ENST00000518215 PPP2R2A-020 26354419-26370363 retained_intron
  ENST00000518254 PPP2R2A-017 26291528-26354630 nonsense_mediated_decay
  ENST00000518397 PPP2R2A-021 26291614-26361012 nonsense_mediated_decay
  ENST00000518890 PPP2R2A-023 26360600-26370391 retained_intron
  ENST00000519439 PPP2R2A-018 26293572-26361085 retained_intron
  ENST00000519636 PPP2R2A-015 26293216-26360182 processed_transcript
  ENST00000520329 PPP2R2A-010 26291528-26360281 nonsense_mediated_decay
  ENST00000520438 PPP2R2A-022 26339919-26360235 processed_transcript
  ENST00000521095 PPP2R2A-009 26292119-26354550 processed_transcript
  ENST00000521484 PPP2R2A-019 26293590-26360238 retained_intron
  ENST00000521557 PPP2R2A-016 26293483-26361033 protein_coding
  ENST00000522150 PPP2R2A-007 26292113-26339973 processed_transcript
  ENST00000522482 PPP2R2A-014 26293217-26354637 processed_transcript
  ENST00000522535 PPP2R2A-006 26291835-26361001 protein_coding
  ENST00000523473 PPP2R2A-008 26292117-26339973 processed_transcript
  ENST00000523925 PPP2R2A-012 26293112-26361007 protein_coding
  ENST00000523964 PPP2R2A-011 26298575-26361044 processed_transcript
  ENST00000524099 PPP2R2A-013 26293206-26360237 processed_transcript
  ENST00000524169 PPP2R2A-004 26291539-26370324 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000315985ENST00000380737ENST00000517754ENST00000518208ENST00000518215ENST00000518397ENST00000518890ENST00000524169
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000315985 16.163±0.00 7.404±0.00 1.487±0.00 13.253±0.00 12.945±0.00 10.577±0.00 9.171±0.00 10.487±0.00 3.471±0.00 8.263±5.69 11.962±0.00 9.328±3.02 8.535±0.00 9.894±4.90
ENST00000380737 2.578±0.00 2.354±0.00 N/A 6.210±0.06 3.026±0.00 2.510±0.00 1.882±0.80 2.264±0.00 1.674±0.52 2.666±1.14 2.807±1.13 3.533±0.89 3.669±1.55 3.021±0.37
ENST00000517754 N/A 1.402±0.00 1.040±0.00 N/A 2.352±0.00 N/A N/A 1.324±0.00 N/A 3.015±0.10 1.072±0.00 2.208±0.00 N/A N/A
ENST00000518208 N/A N/A N/A N/A N/A N/A N/A 2.535±0.00 N/A N/A N/A N/A N/A N/A
ENST00000518215 N/A N/A N/A 5.204±0.00 5.644±0.00 N/A 3.170±0.00 N/A 7.166±0.00 5.539±0.00 N/A 9.434±0.00 N/A N/A
ENST00000518397 N/A N/A N/A N/A N/A 6.498±0.00 N/A N/A N/A N/A N/A 10.216±0.00 14.019±0.00 9.369±0.00
ENST00000518890 N/A N/A 1.726±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000524169 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 22.348±0.00 27.726±0.00 18.217±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007MZ CIL_0007MZ_0001 UCNEbase 8:25894448-26370810
CIL_0005TB CIL_0005TB_0002 CGP 8:26291491-26505636

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000086 TAS G2/M transition of mitotic cell cycle
GO:0000159 IEA:IDA protein phosphatase type 2A complex
GO:0000184 TAS nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000278 TAS mitotic cell cycle
GO:0004722 IDA protein serine/threonine phosphatase activity
GO:0005515 IPI:IEA protein binding
GO:0005654 TAS nucleoplasm
GO:0005829 TAS cytosol
GO:0006470 IDA protein dephosphorylation
GO:0007084 TAS mitotic nuclear envelope reassembly
GO:0007165 IEA signal transduction
GO:0008601 IEA:TAS protein phosphatase type 2A regulator activity
GO:0010467 TAS gene expression
GO:0016070 TAS RNA metabolic process
GO:0016071 TAS mRNA metabolic process
GO:0043278 IEA response to morphine
GO:0050790 IEA regulation of catalytic activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000006624 ppp2r2ab protein phosphatase 2, regulatory subunit B, alpha b protein_coding Danio_rerio
ENSDARG00000021996 PPP2R2A (2 of 2) protein phosphatase 2, regulatory subunit B, alpha protein_coding Danio_rerio
ENSMUSG00000022052 Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha protein_coding Mus_musculus

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