C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: major histocompatibility complex, class II, DP alpha 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000231389 HLA-DPA1 9606 - 6:33064569-33080775 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000417724 HLA-DPA1-004 33073502-33080775 protein_coding
  ENST00000419277 HLA-DPA1-001 33064569-33080710 protein_coding
  ENST00000437811 HLA-DPA1-008 33067660-33069248 protein_coding
  ENST00000453337 HLA-DPA1-002 33069019-33080767 protein_coding
  ENST00000463066 HLA-DPA1-007 33069162-33073633 processed_transcript
  ENST00000476642 HLA-DPA1-005 33069104-33080755 processed_transcript
  ENST00000479107 HLA-DPA1-003 33065007-33073615 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonKidneyLiverMuscleOvaryPlacentaTestisENST00000419277ENST00000453337ENST00000476642ENST00000479107
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Kidney Liver Muscle Ovary Placenta Testis
ENST00000419277 51.597±0.00 220.062±0.00 4.861±0.00 2.608±0.00 33.429±23.17 6.659±0.00 8.885±0.00 6.811±0.00 1.688±0.00 13.267±7.30 15.643±2.01 12.435±7.46
ENST00000453337 N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.863±0.00 N/A N/A
ENST00000476642 58.476±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000479107 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.765±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001PI CIL_0001PI_0002 CGP 6:33004178-33080775
CIL_0001PL CIL_0001PL_0008 CGP 6:33064569-33087201

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000139 TAS Golgi membrane
GO:0002504 IEA antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO:0005515 IEA protein binding
GO:0005765 TAS lysosomal membrane
GO:0005768 IEA endosome
GO:0005886 TAS plasma membrane
GO:0005887 NAS integral component of plasma membrane
GO:0006955 IEA:NAS immune response
GO:0009986 IMP cell surface
GO:0012507 TAS ER to Golgi transport vesicle membrane
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0019221 TAS cytokine-mediated signaling pathway
GO:0019882 IEA antigen processing and presentation
GO:0019886 IMP antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0030658 TAS transport vesicle membrane
GO:0030666 TAS endocytic vesicle membrane
GO:0030669 TAS clathrin-coated endocytic vesicle membrane
GO:0031295 TAS T cell costimulation
GO:0032395 NAS MHC class II receptor activity
GO:0032588 TAS trans-Golgi network membrane
GO:0032729 IMP positive regulation of interferon-gamma production
GO:0042102 IMP positive regulation of T cell proliferation
GO:0042605 IDA peptide antigen binding
GO:0042613 IEA:IDA MHC class II protein complex
GO:0050852 TAS T cell receptor signaling pathway
GO:0050870 IMP positive regulation of T cell activation
GO:0060333 TAS interferon-gamma-mediated signaling pathway
GO:0071346 IDA cellular response to interferon-gamma
GO:0071556 TAS integral component of lumenal side of endoplasmic reticulum membrane

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000001832 si:ch1073-403i13.1 si:ch1073-403i13.1 protein_coding Danio_rerio
ENSDARG00000020286 zgc:123107 zgc:123107 protein_coding Danio_rerio
ENSDARG00000031745 si:busm1-266f07.2 si:busm1-266f07.2 protein_coding Danio_rerio
ENSDARG00000053739 si:busm1-160c18.1 si:busm1-160c18.1 protein_coding Danio_rerio
ENSDARG00000055441 si:busm1-48c11.3 si:busm1-48c11.3 protein_coding Danio_rerio
ENSDARG00000070206 si:zfos-2070c2.1 si:zfos-2070c2.1 protein_coding Danio_rerio
ENSDARG00000074816 si:zfos-367g9.1 si:zfos-367g9.1 protein_coding Danio_rerio
ENSDARG00000075932 si:ch73-211l2.3 si:ch73-211l2.3 protein_coding Danio_rerio
ENSDARG00000079593 si:busm1-228j01.5 si:busm1-228j01.5 protein_coding Danio_rerio
ENSDARG00000086294 CU914776.1 Uncharacterized protein protein_coding Danio_rerio

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