C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: macrophage migration inhibitory factor (glycosylation-inhibiting factor)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000240972 MIF 9606 + 22:23894004-23895227 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000215754 MIF-001 23894004-23895226 protein_coding
  ENST00000465752 MIF-002 23894450-23895227 retained_intron
  ENST00000498385 MIF-003 23894698-23895227 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBrainColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000215754ENST00000498385
Transcript ID Adipose Brain Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000215754 22.233±0.00 7.885±0.00 21.092±17.33 22.806±0.00 63.815±59.57 44.331±0.00 63.434±0.00 10.010±8.52 64.272±60.93 215.729±3.91 49.904±0.00
ENST00000498385 N/A N/A N/A N/A N/A N/A N/A N/A 291.728±0.00 178.841±0.00 N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001516 IDA prostaglandin biosynthetic process
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0002906 IEA negative regulation of mature B cell apoptotic process
GO:0004167 IDA dopachrome isomerase activity
GO:0005102 IPI receptor binding
GO:0005125 IDA cytokine activity
GO:0005126 IPI cytokine receptor binding
GO:0005515 IPI protein binding
GO:0005576 IDA extracellular region
GO:0005615 IEA extracellular space
GO:0005737 IEA cytoplasm
GO:0006954 IEA inflammatory response
GO:0007166 IDA cell surface receptor signaling pathway
GO:0007569 IEA cell aging
GO:0008283 IDA cell proliferation
GO:0009986 IDA cell surface
GO:0010629 IDA negative regulation of gene expression
GO:0010739 IDA positive regulation of protein kinase A signaling
GO:0019752 IDA carboxylic acid metabolic process
GO:0030330 IEA DNA damage response, signal transduction by p53 class mediator
GO:0030890 IDA positive regulation of B cell proliferation
GO:0031666 IEA positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0031982 IDA vesicle
GO:0032269 IEA negative regulation of cellular protein metabolic process
GO:0033033 IEA negative regulation of myeloid cell apoptotic process
GO:0033138 IDA positive regulation of peptidyl-serine phosphorylation
GO:0042056 IDA chemoattractant activity
GO:0042127 IEA regulation of cell proliferation
GO:0042327 IDA positive regulation of phosphorylation
GO:0043030 NAS regulation of macrophage activation
GO:0043066 IDA negative regulation of apoptotic process
GO:0043406 IEA positive regulation of MAP kinase activity
GO:0043518 IDA negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045087 IEA innate immune response
GO:0048146 IDA positive regulation of fibroblast proliferation
GO:0050178 IDA phenylpyruvate tautomerase activity
GO:0050715 IDA positive regulation of cytokine secretion
GO:0050731 IDA positive regulation of peptidyl-tyrosine phosphorylation
GO:0050918 IDA positive chemotaxis
GO:0061078 IEA positive regulation of prostaglandin secretion involved in immune response
GO:0061081 IEA positive regulation of myeloid leukocyte cytokine production involved in immune response
GO:0070062 IDA extracellular vesicular exosome
GO:0070207 IPI protein homotrimerization
GO:0070374 IDA positive regulation of ERK1 and ERK2 cascade
GO:0071157 IDA negative regulation of cell cycle arrest
GO:0090238 IEA positive regulation of arachidonic acid secretion
GO:0090344 IDA negative regulation of cell aging
GO:1902166 IDA negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:2000343 IEA positive regulation of chemokine (C-X-C motif) ligand 2 production

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000071336 mif macrophage migration inhibitory factor protein_coding Danio_rerio
ENSMUSG00000033307 Mif macrophage migration inhibitory factor protein_coding Mus_musculus

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