C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: scleraxis basic helix-loop-helix transcription factor
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000260428 SCX 9606 + 8:144266560-144268481 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000567180 SCX-001 144266560-144268481 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLungMuscleOvaryPlacentaTestisENST00000567180
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Lung Muscle Ovary Placenta Testis
ENST00000567180 0.758±0.00 1.711±0.00 0.076±0.00 0.361±0.19 0.904±0.49 2.073±2.00 1.576±1.41 1.981±0.00 2.588±0.00 4.311±2.64 5.182±3.43 0.977±0.44 5.133±1.74

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007SS CIL_0007SS_0001 VISTA 8:143880613-144482307
CIL_00026T CIL_00026T_0001 CGP 8:144148016-144291370
CIL_0006M5 CIL_0006M5_0002 CGP 8:144262102-144291370
CIL_00064A CIL_00064A_0002 CGP 8:144266560-144314722

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001707 ISS mesoderm formation
GO:0001894 ISS tissue homeostasis
GO:0001958 ISS endochondral ossification
GO:0002062 ISS chondrocyte differentiation
GO:0003179 ISS heart valve morphogenesis
GO:0003188 ISS heart valve formation
GO:0003677 ISS DNA binding
GO:0005515 IEA protein binding
GO:0005634 IDA nucleus
GO:0005667 IDA transcription factor complex
GO:0006351 ISS transcription, DNA-templated
GO:0008284 ISS positive regulation of cell proliferation
GO:0010628 ISS positive regulation of gene expression
GO:0030154 ISS cell differentiation
GO:0030199 ISS collagen fibril organization
GO:0030509 ISS BMP signaling pathway
GO:0032967 ISS positive regulation of collagen biosynthetic process
GO:0035914 IEA skeletal muscle cell differentiation
GO:0035989 ISS tendon development
GO:0035990 ISS tendon cell differentiation
GO:0035992 ISS tendon formation
GO:0035993 ISS deltoid tuberosity development
GO:0043066 ISS negative regulation of apoptotic process
GO:0043425 IPI bHLH transcription factor binding
GO:0043565 ISS sequence-specific DNA binding
GO:0045892 IEA negative regulation of transcription, DNA-templated
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0046982 IDA protein heterodimerization activity
GO:0046983 IEA protein dimerization activity
GO:0048706 IEA embryonic skeletal system development
GO:0060008 ISS Sertoli cell differentiation
GO:0060325 IEA face morphogenesis
GO:0061035 ISS regulation of cartilage development
GO:0061036 ISS positive regulation of cartilage development
GO:0061056 IEA sclerotome development
GO:0070888 IDA E-box binding
GO:0071260 IEA cellular response to mechanical stimulus
GO:0071560 IEA cellular response to transforming growth factor beta stimulus
GO:0071773 IEA cellular response to BMP stimulus
GO:2000543 ISS positive regulation of gastrulation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000011635 SCX scleraxis basic helix-loop-helix transcription factor protein_coding Danio_rerio
ENSDARG00000035695 scxa scleraxis homolog A (mouse) protein_coding Danio_rerio
ENSMUSG00000034161 Scx scleraxis protein_coding Mus_musculus

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