C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: chemokine (C-C motif) ligand 5
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000271503 CCL5 9606 - 17:35871491-35880793 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000603197 CCL5-001 35871491-35880508 protein_coding
  ENST00000605140 CCL5-002 35871491-35880793 protein_coding
  ENST00000605509 CCL5-003 35872002-35880291 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000603197ENST00000605140ENST00000605509
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000603197 0.672±0.00 18.040±0.00 N/A 1.468±0.42 1.848±0.00 0.342±0.00 N/A N/A 7.429±0.00 N/A 3.869±1.76 0.981±0.00 1.071±0.21
ENST00000605140 0.939±0.00 21.456±0.00 0.476±0.24 4.763±0.00 2.150±0.85 1.521±0.00 1.195±0.10 2.133±0.73 32.358±31.67 0.811±0.00 2.504±2.08 7.798±5.37 1.385±0.00
ENST00000605509 N/A N/A N/A N/A N/A N/A N/A N/A 0.619±0.00 N/A N/A 1.317±0.00 0.922±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003GO CIL_0003GO_0001 CGP 17:35854946-35880793

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000165 IMP MAPK cascade
GO:0002407 TAS dendritic cell chemotaxis
GO:0002548 IC monocyte chemotaxis
GO:0002676 TAS regulation of chronic inflammatory response
GO:0004435 IDA phosphatidylinositol phospholipase C activity
GO:0004672 IDA protein kinase activity
GO:0005515 IPI protein binding
GO:0005576 TAS:IEA extracellular region
GO:0005615 IEA extracellular space
GO:0005737 IEA cytoplasm
GO:0006468 IDA protein phosphorylation
GO:0006816 IDA calcium ion transport
GO:0006874 IDA cellular calcium ion homeostasis
GO:0006887 IDA exocytosis
GO:0006935 NAS chemotaxis
GO:0006954 IDA inflammatory response
GO:0006955 IEA immune response
GO:0007159 IDA leukocyte cell-cell adhesion
GO:0007186 IDA G-protein coupled receptor signaling pathway
GO:0007267 IDA cell-cell signaling
GO:0008009 IDA:IEA chemokine activity
GO:0009615 TAS response to virus
GO:0009636 IDA response to toxic substance
GO:0010535 TAS positive regulation of activation of JAK2 kinase activity
GO:0010759 IDA positive regulation of macrophage chemotaxis
GO:0010820 IDA positive regulation of T cell chemotaxis
GO:0014068 IDA positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014911 IDA positive regulation of smooth muscle cell migration
GO:0016004 IDA phospholipase activator activity
GO:0030298 IDA receptor signaling protein tyrosine kinase activator activity
GO:0030335 IDA positive regulation of cell migration
GO:0031328 IDA positive regulation of cellular biosynthetic process
GO:0031584 IDA activation of phospholipase D activity
GO:0031663 IDA lipopolysaccharide-mediated signaling pathway
GO:0031726 IPI CCR1 chemokine receptor binding
GO:0031729 TAS CCR4 chemokine receptor binding
GO:0031730 IPI CCR5 chemokine receptor binding
GO:0033634 IDA positive regulation of cell-cell adhesion mediated by integrin
GO:0034097 IEA response to cytokine
GO:0034112 IDA positive regulation of homotypic cell-cell adhesion
GO:0034612 IEA response to tumor necrosis factor
GO:0042056 IDA chemoattractant activity
GO:0042102 IDA positive regulation of T cell proliferation
GO:0042119 IDA neutrophil activation
GO:0042327 IDA positive regulation of phosphorylation
GO:0042379 IPI chemokine receptor binding
GO:0042531 IDA positive regulation of tyrosine phosphorylation of STAT protein
GO:0042803 IDA protein homodimerization activity
GO:0043491 IMP protein kinase B signaling
GO:0043621 IDA protein self-association
GO:0043623 IDA cellular protein complex assembly
GO:0043922 IDA negative regulation by host of viral transcription
GO:0044344 IEP cellular response to fibroblast growth factor stimulus
GO:0045070 TAS positive regulation of viral genome replication
GO:0045071 IDA negative regulation of viral genome replication
GO:0045089 TAS positive regulation of innate immune response
GO:0045744 IDA negative regulation of G-protein coupled receptor protein signaling pathway
GO:0045785 IDA positive regulation of cell adhesion
GO:0045948 NAS positive regulation of translational initiation
GO:0046427 TAS positive regulation of JAK-STAT cascade
GO:0046817 IDA chemokine receptor antagonist activity
GO:0048245 IDA eosinophil chemotaxis
GO:0048246 TAS macrophage chemotaxis
GO:0048661 IDA positive regulation of smooth muscle cell proliferation
GO:0050679 IEA positive regulation of epithelial cell proliferation
GO:0050796 IDA regulation of insulin secretion
GO:0050863 IDA regulation of T cell activation
GO:0050918 IDA positive chemotaxis
GO:0051262 IDA protein tetramerization
GO:0051928 IDA positive regulation of calcium ion transport
GO:0061098 IDA positive regulation of protein tyrosine kinase activity
GO:0070098 IDA chemokine-mediated signaling pathway
GO:0070100 IDA negative regulation of chemokine-mediated signaling pathway
GO:0070233 IDA negative regulation of T cell apoptotic process
GO:0070234 IDA positive regulation of T cell apoptotic process
GO:0071346 IEP cellular response to interferon-gamma
GO:0071347 IEP cellular response to interleukin-1
GO:0071356 IEP cellular response to tumor necrosis factor
GO:0071407 IDA cellular response to organic cyclic compound
GO:0090026 IDA positive regulation of monocyte chemotaxis
GO:1901214 IDA regulation of neuron death
GO:2000110 IEA negative regulation of macrophage apoptotic process
GO:2000406 IDA positive regulation of T cell migration
GO:2000503 IDA positive regulation of natural killer cell chemotaxis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000035042 Ccl5 chemokine (C-C motif) ligand 5 protein_coding Mus_musculus

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