C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000273259 SERPINA3 9606 + 14:94592058-94624646 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000393078 SERPINA3-201 94612377-94624052 protein_coding
  ENST00000553947 SERPINA3-001 94592058-94624646 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaENST00000393078
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta
ENST00000393078 7.928±0.00 35.984±0.00 42.411±41.24 17.165±4.97 19.539±18.93 10.310±9.30 500.425±41.11 2233.380±2230.01 28.253±25.50 1.076±0.00 45.959±44.11 24.585±22.19

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000598 CIL_000598_0007 CGP 14:94561091-94593120
CIL_000598 CIL_000598_000C CGP 14:94561442-94624646
CIL_000598 CIL_000598_000E CGP 14:94592058-94624646

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003677 TAS DNA binding
GO:0004867 IBA serine-type endopeptidase inhibitor activity
GO:0005515 IPI protein binding
GO:0005576 IBA extracellular region
GO:0005615 IEA:IDA extracellular space
GO:0005622 NAS intracellular
GO:0005634 TAS nucleus
GO:0006953 IEA acute-phase response
GO:0006954 NAS inflammatory response
GO:0010951 IBA negative regulation of endopeptidase activity
GO:0019216 NAS regulation of lipid metabolic process
GO:0030162 IBA regulation of proteolysis
GO:0030277 NAS maintenance of gastrointestinal epithelium
GO:0070062 IDA extracellular vesicular exosome
GO:0072562 IDA blood microparticle

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000074712 si:ch211-186e20.2 si:ch211-186e20.2 protein_coding Danio_rerio
ENSDARG00000077960 si:ch211-186e20.7 si:ch211-186e20.7 protein_coding Danio_rerio
ENSDARG00000087143 serpina7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 protein_coding Danio_rerio
ENSDARG00000090286 serpina1 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 protein_coding Danio_rerio
ENSDARG00000090850 serpina1l serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1, like protein_coding Danio_rerio
ENSDARG00000090916 CR559930.2 Uncharacterized protein protein_coding Danio_rerio
ENSDARG00000091136 zgc:174259 zgc:174259 protein_coding Danio_rerio
ENSDARG00000091800 zgc:174260 zgc:174260 protein_coding Danio_rerio
ENSMUSG00000021091 Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N protein_coding Mus_musculus
ENSMUSG00000041481 Serpina3g serine (or cysteine) peptidase inhibitor, clade A, member 3G protein_coding Mus_musculus
ENSMUSG00000041536 Serpina3a serine (or cysteine) peptidase inhibitor, clade A, member 3A protein_coding Mus_musculus
ENSMUSG00000058207 Serpina3k serine (or cysteine) peptidase inhibitor, clade A, member 3K protein_coding Mus_musculus
ENSMUSG00000066361 Serpina3c serine (or cysteine) peptidase inhibitor, clade A, member 3C protein_coding Mus_musculus
ENSMUSG00000066363 Serpina3f serine (or cysteine) peptidase inhibitor, clade A, member 3F protein_coding Mus_musculus
ENSMUSG00000066364 Serpina3b serine (or cysteine) peptidase inhibitor, clade A, member 3B protein_coding Mus_musculus
ENSMUSG00000079012 Serpina3m serine (or cysteine) peptidase inhibitor, clade A, member 3M protein_coding Mus_musculus
ENSMUSG00000079013 Serpina3j serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3J protein_coding Mus_musculus
ENSMUSG00000079014 Serpina3i serine (or cysteine) peptidase inhibitor, clade A, member 3I protein_coding Mus_musculus

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