C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: inducible T-cell co-stimulator ligand
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000277117 ICOSLG 9606 + 21:5022493-5040666 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000612610 ICOSLG-003 5022493-5040661 protein_coding
  ENST00000620481 ICOSLG-201 5022493-5040666 protein_coding
  ENST00000623795 ICOSLG-004 5022533-5036125 protein_coding
  ENST00000623903 ICOSLG-002 5022531-5034684 nonsense_mediated_decay
  ENST00000623960 ICOSLG-001 5022494-5036771 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000623795ENST00000623960
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000623795 N/A N/A 0.030±0.00 0.257±0.00 0.052±0.00 0.036±0.00 0.141±0.00 0.287±0.00 0.022±0.00 N/A N/A 0.098±0.05 N/A
ENST00000623960 0.079±0.00 0.046±0.00 N/A 0.091±0.04 N/A 0.031±0.00 0.044±0.00 0.116±0.00 N/A 0.080±0.00 0.025±0.01 0.023±0.00 0.059±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00066U CIL_00066U_0001 CGP 21:5011799-5040666
CIL_00066M CIL_00066M_0001 CGP 21:5022493-5128425

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005102 TAS receptor binding
GO:0005515 IEA protein binding
GO:0005886 TAS plasma membrane
GO:0006952 NAS defense response
GO:0006972 NAS hyperosmotic response
GO:0007165 NAS signal transduction
GO:0016021 NAS integral component of membrane
GO:0031295 TAS T cell costimulation
GO:0042104 TAS positive regulation of activated T cell proliferation
GO:0042110 NAS T cell activation
GO:0042113 IEA B cell activation
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000000732 Icosl icos ligand protein_coding Mus_musculus

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