C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: v-raf-leukemia viral oncogene 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000000441 Raf1 10090 - 6:115618067-115676635 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000000451 Raf1-001 115618569-115676635 protein_coding
  ENSMUST00000112949 Raf1-003 115618569-115675964 protein_coding
  ENSMUST00000124553 Raf1-005 115622874-115630726 processed_transcript
  ENSMUST00000127503 Raf1-002 115630198-115676635 retained_intron
  ENSMUST00000130528 Raf1-006 115618067-115634621 retained_intron
  ENSMUST00000147979 Raf1-004 115626284-115632995 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000000451ENSMUST00000112949ENSMUST00000130528
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000000451 51.875±8.75 44.357±2.59 33.920±4.36 42.894±23.00 45.589±5.66 46.426±4.80 46.035±9.12 35.629±2.98 33.501±3.04 45.839±1.52 42.481±2.73 52.506±11.23 34.951±10.40 16.947±0.78
ENSMUST00000112949 15.432±0.16 N/A N/A N/A 14.570±0.00 N/A N/A N/A N/A N/A N/A 10.176±0.43 N/A N/A
ENSMUST00000130528 N/A N/A 6.532±0.65 12.884±0.39 9.634±0.00 N/A N/A N/A 6.276±0.83 N/A 5.624±0.25 7.558±1.51 6.624±0.71 4.934±0.07

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004KF CIL_0004KF_0002 CGP 6:115583544-115618670
CIL_0005SJ CIL_0005SJ_0002 CGP 6:115601938-115676635
CIL_0005SC CIL_0005SC_0002 CGP 6:115618067-115762466

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000165 IEA MAPK cascade
GO:0000186 IEA activation of MAPKK activity
GO:0001666 IEA response to hypoxia
GO:0004672 TAS protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004709 IEA MAP kinase kinase kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005737 ISS cytoplasm
GO:0005739 IEA mitochondrion
GO:0005794 ISO Golgi apparatus
GO:0005829 TAS cytosol
GO:0005886 ISS plasma membrane
GO:0007507 IEA heart development
GO:0008285 IEA negative regulation of cell proliferation
GO:0017016 IPI Ras GTPase binding
GO:0030154 IGI cell differentiation
GO:0031143 IDA pseudopodium
GO:0031333 IEA negative regulation of protein complex assembly
GO:0031434 IEA mitogen-activated protein kinase kinase binding
GO:0033138 IEA positive regulation of peptidyl-serine phosphorylation
GO:0035019 IGI somatic stem cell maintenance
GO:0035556 TAS intracellular signal transduction
GO:0042802 IEA identical protein binding
GO:0043066 IEA negative regulation of apoptotic process
GO:0045104 IMP intermediate filament cytoskeleton organization
GO:0046872 IEA metal ion binding
GO:0046982 IEA protein heterodimerization activity
GO:0048011 IMP neurotrophin TRK receptor signaling pathway
GO:0071550 IMP death-inducing signaling complex assembly
GO:1902042 IGI negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000009875 raf1a v-raf-1 murine leukemia viral oncogene homolog 1a protein_coding Danio_rerio
ENSDARG00000059406 raf1b v-raf-1 murine leukemia viral oncogene homolog 1b protein_coding Danio_rerio
ENSDARG00000096415 raf1a v-raf-1 murine leukemia viral oncogene homolog 1a protein_coding Danio_rerio
ENSG00000132155 RAF1 Raf-1 proto-oncogene, serine/threonine kinase protein_coding Homo_sapiens

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