C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: serine/threonine kinase 11
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000003068 Stk11 10090 + 10:80115803-80130682 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000003152 Stk11-001 80115803-80130682 protein_coding
  ENSMUST00000105370 Stk11-003 80125375-80130675 protein_coding
  ENSMUST00000105371 Stk11-004 80116347-80130470 nonsense_mediated_decay
  ENSMUST00000128992 Stk11-005 80116354-80117814 processed_transcript
  ENSMUST00000129235 Stk11-008 80125375-80126509 retained_intron
  ENSMUST00000144108 Stk11-009 80126386-80128199 retained_intron
  ENSMUST00000144119 Stk11-007 80124819-80129975 retained_intron
  ENSMUST00000144883 Stk11-002 80115803-80130469 nonsense_mediated_decay
  ENSMUST00000152592 Stk11-006 80126682-80130470 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastHeartLiverLungMuscleOvaryPlacentaTestisENSMUST00000003152ENSMUST00000105370ENSMUST00000105371ENSMUST00000144108ENSMUST00000144119ENSMUST00000144883ENSMUST00000152592
Transcript ID Adipose Bladder Brain Breast Heart Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000003152 43.592±4.81 25.706±0.99 23.217±2.47 N/A 28.446±0.00 29.831±5.22 62.674±10.75 33.696±3.49 26.060±0.00 22.375±3.97 20.851±1.80
ENSMUST00000105370 N/A N/A N/A N/A N/A N/A N/A N/A N/A 33.760±0.00 N/A
ENSMUST00000105371 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 30.166±6.75
ENSMUST00000144108 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 97.146±0.00
ENSMUST00000144119 N/A N/A 136.103±0.00 29.179±0.00 N/A N/A N/A N/A 82.617±38.94 150.361±24.73 152.225±0.00
ENSMUST00000144883 N/A N/A N/A N/A N/A 16.751±0.75 N/A N/A 9.747±0.00 N/A 17.959±2.74
ENSMUST00000152592 N/A N/A N/A N/A N/A N/A N/A N/A 108.222±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008XG CIL_0008XG_0002 VISTA 10:79539861-80142369
CIL_0000QW CIL_0000QW_0002 CGP 10:80057416-80130682
CIL_0005ZG CIL_0005ZG_0003 CGP 10:80115803-80140835

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000287 ISS magnesium ion binding
GO:0001558 IDA regulation of cell growth
GO:0001894 IMP tissue homeostasis
GO:0001944 IMP vasculature development
GO:0002039 ISS p53 binding
GO:0004674 ISS protein serine/threonine kinase activity
GO:0005515 IPI protein binding
GO:0005524 ISS ATP binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005739 ISS mitochondrion
GO:0005829 IDA cytosol
GO:0006468 ISS protein phosphorylation
GO:0006914 IEA autophagy
GO:0006974 IEA cellular response to DNA damage stimulus
GO:0007050 ISS cell cycle arrest
GO:0007283 IEA spermatogenesis
GO:0007286 IMP spermatid development
GO:0007409 IMP axonogenesis
GO:0008152 IEA metabolic process
GO:0008285 IEA negative regulation of cell proliferation
GO:0010212 IDA response to ionizing radiation
GO:0016020 IDA membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0030010 IMP establishment of cell polarity
GO:0030111 IMP regulation of Wnt signaling pathway
GO:0030275 IPI LRR domain binding
GO:0030295 IMP protein kinase activator activity
GO:0030308 IDA negative regulation of cell growth
GO:0030511 IMP positive regulation of transforming growth factor beta receptor signaling pathway
GO:0032147 IDA activation of protein kinase activity
GO:0032403 IEA protein complex binding
GO:0033762 IEA response to glucagon
GO:0033993 IEA response to lipid
GO:0036398 IDA TCR signalosome
GO:0036399 IMP TCR signalosome assembly
GO:0042593 IMP glucose homeostasis
GO:0043234 IEA protein complex
GO:0043276 IEA anoikis
GO:0043434 IEA response to peptide hormone
GO:0045059 IMP positive thymic T cell selection
GO:0045722 IEA positive regulation of gluconeogenesis
GO:0046777 IDA protein autophosphorylation
GO:0050731 IMP positive regulation of peptidyl-tyrosine phosphorylation
GO:0050772 IGI positive regulation of axonogenesis
GO:0050852 IGI T cell receptor signaling pathway
GO:0051291 IEA protein heterooligomerization
GO:0051645 IMP Golgi localization
GO:0051896 IMP regulation of protein kinase B signaling
GO:0060070 IMP canonical Wnt signaling pathway
GO:0060770 IMP negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0070062 IEA extracellular vesicular exosome
GO:0072332 ISS intrinsic apoptotic signaling pathway by p53 class mediator

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000046074 stk11 serine/threonine kinase 11 protein_coding Danio_rerio
ENSG00000118046 STK11 serine/threonine kinase 11 protein_coding Homo_sapiens

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