C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: insulin receptor
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000005534 Insr 10090 - 8:3150922-3279617 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000091291 Insr-001 3150922-3279617 protein_coding
  ENSMUST00000139504 Insr-002 3211101-3279551 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000091291ENSMUST00000139504
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000091291 6.321±1.15 6.734±2.23 5.427±2.18 4.457±2.25 5.101±1.44 5.425±1.26 10.255±0.42 4.584±2.36 3.414±2.60 5.747±1.39 6.634±0.60 6.338±2.30 2.710±2.02 1.930±0.40
ENSMUST00000139504 N/A 13.849±3.40 N/A N/A 5.772±0.00 7.384±1.71 N/A N/A N/A 4.933±0.00 N/A 8.622±3.35 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000434 CIL_000434_0002 CGP 8:3150922-3390295

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000187 IEA activation of MAPK activity
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0003007 IEA heart morphogenesis
GO:0004716 IEA receptor signaling protein tyrosine kinase activity
GO:0005009 ISS insulin-activated receptor activity
GO:0005159 IEA insulin-like growth factor receptor binding
GO:0005515 IPI protein binding
GO:0005525 IEA GTP binding
GO:0005886 IDA plasma membrane
GO:0005887 IEA integral component of plasma membrane
GO:0005899 IEA insulin receptor complex
GO:0005901 IDA caveola
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0008286 IMP insulin receptor signaling pathway
GO:0008544 IMP epidermis development
GO:0009887 IMP organ morphogenesis
GO:0016020 IDA membrane
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0019087 IEA transformation of host cell by virus
GO:0023014 IEA signal transduction by phosphorylation
GO:0030238 IMP male sex determination
GO:0030335 IEA positive regulation of cell migration
GO:0031017 IMP exocrine pancreas development
GO:0031994 IEA insulin-like growth factor I binding
GO:0031995 IEA insulin-like growth factor II binding
GO:0032147 IEA activation of protein kinase activity
GO:0032148 IEA activation of protein kinase B activity
GO:0032869 IEA cellular response to insulin stimulus
GO:0038083 IDA peptidyl-tyrosine autophosphorylation
GO:0042593 IEA glucose homeostasis
GO:0043235 ISO receptor complex
GO:0043410 IEA positive regulation of MAPK cascade
GO:0043548 ISS phosphatidylinositol 3-kinase binding
GO:0043559 ISS insulin binding
GO:0043560 ISS insulin receptor substrate binding
GO:0045429 IEA positive regulation of nitric oxide biosynthetic process
GO:0045725 IMP positive regulation of glycogen biosynthetic process
GO:0045740 IEA positive regulation of DNA replication
GO:0045821 IEA positive regulation of glycolytic process
GO:0045840 IMP positive regulation of mitosis
GO:0045995 IEA regulation of embryonic development
GO:0046777 ISS protein autophosphorylation
GO:0048639 IEA positive regulation of developmental growth
GO:0051290 ISS protein heterotetramerization
GO:0051425 ISS PTB domain binding
GO:0051897 IEA positive regulation of protein kinase B signaling
GO:0060267 IEA positive regulation of respiratory burst
GO:0070062 IEA extracellular vesicular exosome
GO:0071363 IDA cellular response to growth factor stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000011948 insra insulin receptor a protein_coding Danio_rerio
ENSDARG00000071524 insrb insulin receptor b protein_coding Danio_rerio
ENSG00000171105 INSR insulin receptor protein_coding Homo_sapiens

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