C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: transducin-like enhancer of split 1, homolog of Drosophila E(spl)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000008305 Tle1 10090 - 4:72117142-72200919 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000030095 Tle1-008 72118205-72200152 protein_coding
  ENSMUST00000072695 Tle1-001 72117805-72200857 protein_coding
  ENSMUST00000074216 Tle1-201 72117142-72200919 protein_coding
  ENSMUST00000102848 Tle1-006 72117807-72200854 protein_coding
  ENSMUST00000107337 Tle1-002 72157580-72200862 protein_coding
  ENSMUST00000123259 Tle1-009 72118220-72120734 processed_transcript
  ENSMUST00000132550 Tle1-005 72117810-72199092 retained_intron
  ENSMUST00000134225 Tle1-004 72167182-72200893 processed_transcript
  ENSMUST00000137075 Tle1-007 72158272-72199492 protein_coding
  ENSMUST00000140154 Tle1-003 72138588-72141313 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000030095ENSMUST00000072695ENSMUST00000074216ENSMUST00000102848ENSMUST00000107337ENSMUST00000132550ENSMUST00000137075
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000030095 6.501±0.76 N/A 3.541±0.25 N/A 2.968±0.83 3.967±0.41 0.865±0.26 1.883±0.45 4.603±1.86 4.582±1.28 0.953±0.17 7.901±1.58 1.549±0.34 1.531±0.59
ENSMUST00000072695 8.324±3.62 8.994±4.39 5.258±0.62 9.497±3.12 5.576±1.64 6.101±2.15 0.879±0.30 2.224±0.80 4.378±1.97 4.911±1.73 1.659±0.70 11.382±4.09 2.082±0.78 1.842±0.67
ENSMUST00000074216 6.344±0.51 4.059±0.99 N/A 5.957±0.34 2.447±0.54 2.376±0.73 0.358±0.14 1.248±0.00 1.847±1.09 6.179±2.86 0.330±0.00 10.663±3.81 0.638±0.00 0.732±0.00
ENSMUST00000102848 N/A 2.722±0.01 N/A 2.079±0.00 2.172±0.00 1.678±0.00 N/A 0.800±0.05 N/A 1.710±0.13 0.756±0.28 4.072±0.62 N/A 0.701±0.00
ENSMUST00000107337 10.127±1.69 7.993±1.58 6.551±0.08 13.283±0.00 5.363±0.70 6.546±1.60 0.938±0.01 3.047±1.08 9.760±4.06 7.597±1.54 2.732±0.56 11.474±2.79 2.620±0.95 2.386±0.23
ENSMUST00000132550 N/A 7.080±0.13 N/A 8.017±0.02 N/A N/A N/A 2.155±0.00 N/A N/A N/A 12.219±0.00 N/A N/A
ENSMUST00000137075 N/A N/A N/A 20.770±0.00 N/A N/A N/A N/A N/A N/A N/A 30.617±0.00 6.732±1.46 3.806±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007KE CIL_0007KE_0004 UCNEbase 4:70810873-73489292
CIL_00090V CIL_00090V_0002 VISTA 4:71539683-72141070
CIL_0008X3 CIL_0008X3_0002 VISTA 4:71768926-72369840
CIL_0009AO CIL_0009AO_0002 VISTA 4:71866327-72468960
CIL_0008C4 CIL_0008C4_0002 VISTA 4:71896487-72497365
CIL_0008TV CIL_0008TV_0002 VISTA 4:72081989-72683115

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0001106 IEA RNA polymerase II transcription corepressor activity
GO:0003682 IDA chromatin binding
GO:0003714 IDA transcription corepressor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005667 IDA transcription factor complex
GO:0005730 IEA nucleolus
GO:0005737 IEA cytoplasm
GO:0005829 IEA cytosol
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0006357 IGI regulation of transcription from RNA polymerase II promoter
GO:0008134 IEA transcription factor binding
GO:0010628 IEA positive regulation of gene expression
GO:0016055 IEA Wnt signaling pathway
GO:0042802 IEA identical protein binding
GO:0043124 IEA negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045892 IEA negative regulation of transcription, DNA-templated
GO:2000811 IEA negative regulation of anoikis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000067832 TLE6 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) protein_coding Danio_rerio
ENSG00000196781 TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) protein_coding Homo_sapiens

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