C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: neurofibromatosis 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000009073 Nf2 10090 - 11:4765845-4849536 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000053079 Nf2-004 4772334-4849365 protein_coding
  ENSMUST00000056290 Nf2-002 4767665-4848985 protein_coding
  ENSMUST00000093374 Nf2-013 4779814-4820396 protein_coding
  ENSMUST00000109908 Nf2-003 4781937-4833133 processed_transcript
  ENSMUST00000109910 Nf2-001 4765845-4849536 protein_coding
  ENSMUST00000124878 Nf2-005 4799861-4820396 nonsense_mediated_decay
  ENSMUST00000137926 Nf2-012 4794480-4818547 protein_coding
  ENSMUST00000141342 Nf2-009 4767953-4785107 retained_intron
  ENSMUST00000152656 Nf2-008 4784436-4816165 nonsense_mediated_decay
  ENSMUST00000155600 Nf2-006 4794431-4815240 processed_transcript
  ENSMUST00000164190 Nf2-007 4791201-4849194 protein_coding
  ENSMUST00000167480 Nf2-011 4818505-4824921 processed_transcript
  ENSMUST00000172305 Nf2-010 4829843-4849125 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverOvaryPlacentaTestisENSMUST00000056290ENSMUST00000093374ENSMUST00000109910
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Ovary Placenta Testis
ENSMUST00000056290 N/A N/A N/A 5.241±0.00 N/A N/A N/A N/A N/A 3.922±0.00 2.709±1.36 4.675±0.00
ENSMUST00000093374 N/A N/A N/A N/A N/A N/A N/A N/A N/A 14.158±0.00 N/A N/A
ENSMUST00000109910 8.233±0.71 8.107±0.00 2.967±0.02 12.310±10.24 4.432±1.20 6.698±0.00 13.771±0.62 12.289±8.70 4.896±2.91 5.594±1.88 3.738±2.65 23.986±3.97

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003VP CIL_0003VP_0002 CGP 11:4736892-4849536

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001707 IMP mesoderm formation
GO:0001726 IDA ruffle
GO:0003779 IEA actin binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005730 IEA nucleolus
GO:0005737 IDA cytoplasm
GO:0005769 IEA early endosome
GO:0005856 IDA cytoskeleton
GO:0005886 IEA plasma membrane
GO:0005912 IMP adherens junction
GO:0006469 IDA negative regulation of protein kinase activity
GO:0007398 IMP ectoderm development
GO:0007420 IMP brain development
GO:0008092 IEA cytoskeletal protein binding
GO:0008156 IEA negative regulation of DNA replication
GO:0008285 IMP negative regulation of cell proliferation
GO:0014010 IEA Schwann cell proliferation
GO:0016020 IEA membrane
GO:0019898 IEA extrinsic component of membrane
GO:0021766 IMP hippocampus development
GO:0022408 IEA negative regulation of cell-cell adhesion
GO:0030027 IDA lamellipodium
GO:0030036 IEA actin cytoskeleton organization
GO:0030175 IDA filopodium
GO:0030864 IDA cortical actin cytoskeleton
GO:0031647 IMP regulation of protein stability
GO:0032154 IDA cleavage furrow
GO:0035330 IEA regulation of hippo signaling
GO:0042127 IMP regulation of cell proliferation
GO:0042475 IMP odontogenesis of dentin-containing tooth
GO:0042518 IEA negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0042524 IEA negative regulation of tyrosine phosphorylation of Stat5 protein
GO:0043409 IMP negative regulation of MAPK cascade
GO:0045177 IDA apical part of cell
GO:0045216 IMP cell-cell junction organization
GO:0045597 IMP positive regulation of cell differentiation
GO:0046426 IEA negative regulation of JAK-STAT cascade
GO:0048471 IEA perinuclear region of cytoplasm
GO:0051496 IEA positive regulation of stress fiber assembly
GO:0070306 IMP lens fiber cell differentiation
GO:1900180 IMP regulation of protein localization to nucleus
GO:2000177 IMP regulation of neural precursor cell proliferation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000020204 nf2a neurofibromin 2a (merlin) protein_coding Danio_rerio
ENSG00000186575 NF2 neurofibromin 2 (merlin) protein_coding Homo_sapiens

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