C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: MKL/myocardin-like 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000009569 Mkl2 10090 + 16:13256481-13417529 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000009713 Mkl2-003 13256481-13415063 protein_coding
  ENSMUST00000056715 Mkl2-201 13265076-13332919 protein_coding
  ENSMUST00000115809 Mkl2-004 13256506-13332922 protein_coding
  ENSMUST00000149359 Mkl2-001 13358421-13417529 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000009713ENSMUST00000149359
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000009713 N/A 1.607±0.64 N/A N/A N/A 1.245±0.00 N/A N/A N/A 1.509±0.32 N/A 1.132±0.16 N/A 1.561±0.88
ENSMUST00000149359 3.075±2.36 3.439±0.68 1.317±0.00 5.890±3.72 2.597±1.45 2.803±1.32 1.135±0.00 0.566±0.25 0.835±0.50 6.321±1.80 1.188±0.60 3.356±1.64 3.317±1.00 3.247±0.21

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002RP CIL_0002RP_0003 CGP 16:13109684-13417529
CIL_0007DW CIL_0007DW_0002 CGP 16:13256481-13668170

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001701 IMP in utero embryonic development
GO:0001889 IMP liver development
GO:0003007 IMP heart morphogenesis
GO:0003676 IEA nucleic acid binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0003713 IEA transcription coactivator activity
GO:0003779 IDA actin binding
GO:0005515 IPI protein binding
GO:0005737 IDA cytoplasm
GO:0007507 IMP heart development
GO:0010467 IMP gene expression
GO:0010468 IMP regulation of gene expression
GO:0045844 IEA positive regulation of striated muscle tissue development
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0048514 IMP blood vessel morphogenesis
GO:0048568 IMP embryonic organ development
GO:0048738 IMP cardiac muscle tissue development
GO:0051145 IMP smooth muscle cell differentiation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000076704 MKL2 (1 of 3) MKL/myocardin-like 2 protein_coding Danio_rerio
ENSDARG00000076867 mkl2b MKL/myocardin-like 2b protein_coding Danio_rerio
ENSDARG00000088307 mkl2a MKL/myocardin-like 2a protein_coding Danio_rerio
ENSG00000186260 MKL2 MKL/myocardin-like 2 protein_coding Homo_sapiens

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