C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: topoisomerase (DNA) II alpha
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000020914 Top2a 10090 - 11:98992943-99024189 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000068031 Top2a-001 98992943-99024189 protein_coding
  ENSMUST00000129777 Top2a-003 99022085-99024178 processed_transcript
  ENSMUST00000139460 Top2a-007 98993467-98995370 processed_transcript
  ENSMUST00000139730 Top2a-002 99016593-99022210 processed_transcript
  ENSMUST00000144318 Top2a-004 99003625-99006522 processed_transcript
  ENSMUST00000151997 Top2a-005 98999947-99001260 processed_transcript
  ENSMUST00000154332 Top2a-008 98993071-98995724 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000068031ENSMUST00000139460ENSMUST00000144318ENSMUST00000154332
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000068031 0.960±1.24 0.200±0.07 1.218±0.04 11.221±1.52 0.538±0.19 2.387±0.63 0.078±0.02 0.177±0.06 19.687±24.26 0.481±0.18 0.032±0.02 4.207±4.34 18.394±13.92 12.166±6.73
ENSMUST00000139460 N/A N/A N/A N/A N/A N/A 0.138±0.03 N/A 0.117±0.02 N/A 0.159±0.00 1.992±0.00 N/A N/A
ENSMUST00000144318 N/A N/A N/A N/A 0.884±0.12 1.883±0.07 N/A N/A N/A N/A 0.067±0.00 N/A N/A N/A
ENSMUST00000154332 N/A 0.517±0.11 N/A N/A N/A 3.245±0.00 N/A 0.515±0.19 0.298±0.11 N/A 0.091±0.00 2.375±0.88 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00098Y CIL_00098Y_0002 VISTA 11:98447152-99051430
CIL_0007HC CIL_0007HC_0002 CGP 11:98982180-99024189
CIL_0005R1 CIL_0005R1_0002 CGP 11:98992943-99054392

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000228 IEA nuclear chromosome
GO:0000287 ISS magnesium ion binding
GO:0000712 IBA resolution of meiotic recombination intermediates
GO:0000793 IDA condensed chromosome
GO:0000819 IBA sister chromatid segregation
GO:0002244 IMP hematopoietic progenitor cell differentiation
GO:0003682 IEA chromatin binding
GO:0003918 IDA DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005080 IEA protein kinase C binding
GO:0005515 IEA protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005654 IEA nucleoplasm
GO:0005730 IDA nucleolus
GO:0005814 IEA centriole
GO:0006200 IEA ATP catabolic process
GO:0006265 IDA DNA topological change
GO:0006266 IEA DNA ligation
GO:0006268 IBA DNA unwinding involved in DNA replication
GO:0006312 IBA mitotic recombination
GO:0006974 IEA cellular response to DNA damage stimulus
GO:0007059 IMP chromosome segregation
GO:0008022 IEA protein C-terminus binding
GO:0008094 IEA DNA-dependent ATPase activity
GO:0008144 IEA drug binding
GO:0008301 ISS DNA binding, bending
GO:0009330 IBA DNA topoisomerase complex (ATP-hydrolyzing)
GO:0019899 IEA enzyme binding
GO:0030261 IMP chromosome condensation
GO:0030263 IBA apoptotic chromosome condensation
GO:0040016 IMP embryonic cleavage
GO:0042803 IEA protein homodimerization activity
GO:0042826 IEA histone deacetylase binding
GO:0043065 IEA positive regulation of apoptotic process
GO:0043130 IEA ubiquitin binding
GO:0043234 IEA protein complex
GO:0044774 IBA mitotic DNA integrity checkpoint
GO:0044822 IEA poly(A) RNA binding
GO:0045070 IEA positive regulation of viral genome replication
GO:0045870 IEA positive regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0046982 IEA protein heterodimerization activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000024488 top2a topoisomerase (DNA) II alpha protein_coding Danio_rerio
ENSG00000131747 TOP2A topoisomerase (DNA) II alpha 170kDa protein_coding Homo_sapiens

Loading