C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: large tumor suppressor 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000021959 Lats2 10090 - 14:57642077-57758388 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000022531 Lats2-001 57689662-57746123 protein_coding
  ENSMUST00000038381 Lats2-005 57722189-57734300 protein_coding
  ENSMUST00000077981 Lats2-006 57722189-57734300 protein_coding
  ENSMUST00000173077 Lats2-008 57734253-57746578 processed_transcript
  ENSMUST00000173732 Lats2-009 57734180-57744654 protein_coding
  ENSMUST00000173964 Lats2-010 57697227-57699890 protein_coding
  ENSMUST00000173990 Lats2-003 57693544-57746105 protein_coding
  ENSMUST00000174166 Lats2-007 57703051-57758388 protein_coding
  ENSMUST00000174213 Lats2-002 57691098-57746121 nonsense_mediated_decay
  ENSMUST00000174694 Lats2-004 57642077-57746103 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000022531ENSMUST00000173990ENSMUST00000174213ENSMUST00000174694
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000022531 14.154±1.27 24.088±7.55 15.959±0.57 3.947±0.70 16.936±6.18 11.152±3.95 8.130±0.55 15.762±3.17 3.356±0.75 45.644±6.79 3.644±0.51 25.131±8.75 8.362±4.16 20.080±8.58
ENSMUST00000173990 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 5.478±0.00 N/A 3.281±0.00
ENSMUST00000174213 6.313±0.73 5.806±1.44 N/A N/A 5.964±0.22 6.626±1.35 N/A 6.374±1.52 1.118±0.00 9.021±0.00 N/A 10.062±4.15 N/A 28.494±3.39
ENSMUST00000174694 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 10.351±0.27 N/A 5.953±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003SP CIL_0003SP_0002 CGP 14:57549598-57665430
CIL_0003SQ CIL_0003SQ_0002 CGP 14:57581002-57758388
CIL_0003SR CIL_0003SR_0002 CGP 14:57642077-57804980

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000082 IDA G1/S transition of mitotic cell cycle
GO:0000922 IDA spindle pole
GO:0004674 ISS protein serine/threonine kinase activity
GO:0005524 ISS ATP binding
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0006468 IDA:ISS protein phosphorylation
GO:0007067 IEA mitotic nuclear division
GO:0009755 ISS hormone-mediated signaling pathway
GO:0030216 IGI keratinocyte differentiation
GO:0034613 IDA cellular protein localization
GO:0035329 IGI hippo signaling
GO:0035556 ISS intracellular signal transduction
GO:0045736 ISS negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0046620 IMP regulation of organ growth
GO:0046872 IEA metal ion binding
GO:0090090 IGI negative regulation of canonical Wnt signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000078864 lats2 LATS, large tumor suppressor, homolog 2 (Drosophila) protein_coding Danio_rerio
ENSG00000150457 LATS2 large tumor suppressor kinase 2 protein_coding Homo_sapiens

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