C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: hairy and enhancer of split 1 (Drosophila)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000022528 Hes1 10090 + 16:30064384-30067796 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000023171 Hes1-001 30065340-30067796 protein_coding
  ENSMUST00000160592 Hes1-004 30064384-30065569 processed_transcript
  ENSMUST00000161676 Hes1-003 30066097-30067123 retained_intron
  ENSMUST00000161839 Hes1-002 30066338-30067319 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000023171ENSMUST00000161676ENSMUST00000161839
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000023171 7.682±3.64 22.619±12.11 57.739±14.91 8.707±3.59 14.063±9.52 53.718±11.65 7.751±3.82 15.399±5.15 5.775±1.25 34.966±16.19 5.650±0.80 26.347±10.95 8.124±3.72 1.221±0.62
ENSMUST00000161676 12.095±2.87 52.734±15.54 52.939±13.91 17.061±1.77 81.086±30.92 118.290±34.03 13.028±0.14 22.246±12.30 9.155±2.08 78.146±31.16 N/A 86.659±39.27 8.491±0.06 3.830±0.00
ENSMUST00000161839 3.926±0.00 20.283±5.99 N/A 4.840±0.00 26.666±3.65 65.628±18.83 N/A 9.960±0.00 N/A 30.486±10.47 N/A 66.481±15.61 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007UX CIL_0007UX_0002 VISTA 16:29582436-30184131
CIL_0009B1 CIL_0009B1_0002 VISTA 16:29593116-30195809
CIL_0009A1 CIL_0009A1_0002 VISTA 16:29828808-30430865
CIL_0000N7 CIL_0000N7_0002 CGP 16:30064384-30267532

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000981 IDA sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001078 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001701 IGI in utero embryonic development
GO:0001889 IMP liver development
GO:0003143 IMP embryonic heart tube morphogenesis
GO:0003151 IMP outflow tract morphogenesis
GO:0003266 IMP regulation of secondary heart field cardioblast proliferation
GO:0003281 IMP ventricular septum development
GO:0003677 IDA DNA binding
GO:0003700 ISS sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005622 IDA intracellular
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0006357 IGI regulation of transcription from RNA polymerase II promoter
GO:0006366 IDA transcription from RNA polymerase II promoter
GO:0006461 IDA protein complex assembly
GO:0007155 IGI cell adhesion
GO:0007219 NAS Notch signaling pathway
GO:0007224 IDA smoothened signaling pathway
GO:0007262 IDA STAT protein import into nucleus
GO:0007389 IGI pattern specification process
GO:0008134 NAS transcription factor binding
GO:0008284 IMP positive regulation of cell proliferation
GO:0016477 IGI cell migration
GO:0021537 IGI telencephalon development
GO:0021555 IGI midbrain-hindbrain boundary morphogenesis
GO:0021557 IGI oculomotor nerve development
GO:0021558 IGI trochlear nerve development
GO:0021575 IGI hindbrain morphogenesis
GO:0021861 ISS forebrain radial glial cell differentiation
GO:0021915 IGI neural tube development
GO:0021983 IMP pituitary gland development
GO:0021984 IMP adenohypophysis development
GO:0030324 IMP lung development
GO:0030513 IGI positive regulation of BMP signaling pathway
GO:0030901 IGI midbrain development
GO:0031016 IMP pancreas development
GO:0031018 TAS endocrine pancreas development
GO:0035019 IMP somatic stem cell maintenance
GO:0035909 IMP aorta morphogenesis
GO:0035910 IMP ascending aorta morphogenesis
GO:0042102 IMP positive regulation of T cell proliferation
GO:0042491 IMP auditory receptor cell differentiation
GO:0042517 IDA positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042668 IMP auditory receptor cell fate determination
GO:0042803 IDA protein homodimerization activity
GO:0042826 IEA histone deacetylase binding
GO:0043388 IDA positive regulation of DNA binding
GO:0043565 ISS sequence-specific DNA binding
GO:0045165 IMP cell fate commitment
GO:0045596 IMP negative regulation of cell differentiation
GO:0045598 IMP regulation of fat cell differentiation
GO:0045608 IMP negative regulation of auditory receptor cell differentiation
GO:0045665 IGI negative regulation of neuron differentiation
GO:0045747 IMP positive regulation of Notch signaling pathway
GO:0045892 IMP negative regulation of transcription, DNA-templated
GO:0045893 IMP positive regulation of transcription, DNA-templated
GO:0045944 IGI positive regulation of transcription from RNA polymerase II promoter
GO:0045977 IMP positive regulation of mitotic cell cycle, embryonic
GO:0046331 IMP lateral inhibition
GO:0046427 IDA positive regulation of JAK-STAT cascade
GO:0048469 IGI cell maturation
GO:0048505 IMP regulation of timing of cell differentiation
GO:0048538 IMP thymus development
GO:0048667 IGI cell morphogenesis involved in neuron differentiation
GO:0048711 IDA positive regulation of astrocyte differentiation
GO:0048715 IDA negative regulation of oligodendrocyte differentiation
GO:0048844 IMP artery morphogenesis
GO:0050767 IGI regulation of neurogenesis
GO:0051087 IDA chaperone binding
GO:0060164 IGI regulation of timing of neuron differentiation
GO:0060253 IDA negative regulation of glial cell proliferation
GO:0060412 IMP ventricular septum morphogenesis
GO:0060675 IEP ureteric bud morphogenesis
GO:0060716 IMP labyrinthine layer blood vessel development
GO:0061009 IMP common bile duct development
GO:0061106 IMP negative regulation of stomach neuroendocrine cell differentiation
GO:0061309 IMP cardiac neural crest cell development involved in outflow tract morphogenesis
GO:0061626 IMP pharyngeal arch artery morphogenesis
GO:0071820 IDA N-box binding
GO:0072012 IEP glomerulus vasculature development
GO:0072049 IEP comma-shaped body morphogenesis
GO:0072050 IEP S-shaped body morphogenesis
GO:0072141 IEP renal interstitial fibroblast development
GO:0072282 IEP metanephric nephron tubule morphogenesis
GO:0090102 IGI cochlea development
GO:0097084 IMP vascular smooth muscle cell development
GO:0097150 IMP neuronal stem cell maintenance
GO:2000227 IMP negative regulation of pancreatic A cell differentiation
GO:2000737 IEA negative regulation of stem cell differentiation
GO:2000974 ISS negative regulation of pro-B cell differentiation
GO:2000978 ISS negative regulation of forebrain neuron differentiation
GO:2000981 IMP negative regulation of inner ear receptor cell differentiation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000006514 her6 hairy-related 6 protein_coding Danio_rerio
ENSG00000114315 HES1 hes family bHLH transcription factor 1 protein_coding Homo_sapiens

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