C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: scribbled homolog (Drosophila)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000022568 Scrib 10090 - 15:76047158-76069784 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000002603 Scrib-001 76047158-76069754 protein_coding
  ENSMUST00000063747 Scrib-003 76047158-76069754 protein_coding
  ENSMUST00000109946 Scrib-002 76047158-76069784 protein_coding
  ENSMUST00000136390 Scrib-004 76047158-76062719 protein_coding
  ENSMUST00000145830 Scrib-005 76048940-76050786 protein_coding
  ENSMUST00000148211 Scrib-006 76049203-76050786 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000002603ENSMUST00000063747ENSMUST00000109946ENSMUST00000136390
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000002603 N/A N/A N/A 7.646±2.35 N/A N/A 1.408±0.21 N/A N/A N/A 1.312±0.65 N/A N/A 6.682±1.51
ENSMUST00000063747 10.679±4.46 11.464±3.15 11.885±1.15 10.681±4.95 13.248±5.63 24.117±2.10 3.431±0.83 10.649±1.19 6.836±2.62 15.528±1.33 1.142±0.51 23.276±8.23 9.944±2.08 36.642±4.52
ENSMUST00000109946 N/A N/A N/A 14.635±2.86 N/A N/A N/A N/A 0.814±0.00 N/A N/A N/A N/A N/A
ENSMUST00000136390 3.771±0.16 7.355±0.80 6.570±0.94 8.837±0.00 6.516±0.89 8.496±2.35 2.586±0.66 3.830±1.35 2.294±0.67 5.577±0.33 1.399±0.25 7.462±0.97 5.006±1.40 9.615±0.02

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008C2 CIL_0008C2_0002 VISTA 15:75534812-76135772
CIL_0002GT CIL_0002GT_0002 CGP 15:76047158-76080946

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001843 IMP neural tube closure
GO:0001921 IEA positive regulation of receptor recycling
GO:0002093 IGI auditory receptor cell morphogenesis
GO:0005515 IPI protein binding
GO:0005737 IEA cytoplasm
GO:0005829 TAS cytosol
GO:0005886 ISS plasma membrane
GO:0005911 ISS cell-cell junction
GO:0005913 ISS cell-cell adherens junction
GO:0008105 IMP asymmetric protein localization
GO:0008283 ISS cell proliferation
GO:0016080 IMP synaptic vesicle targeting
GO:0016323 IDA basolateral plasma membrane
GO:0016331 IMP morphogenesis of embryonic epithelium
GO:0016337 ISS single organismal cell-cell adhesion
GO:0016477 IMP cell migration
GO:0021747 IGI cochlear nucleus development
GO:0031252 ISS cell leading edge
GO:0032863 ISS activation of Rac GTPase activity
GO:0034750 IEA Scrib-APC-beta-catenin complex
GO:0035089 ISS establishment of apical/basal cell polarity
GO:0035748 IDA myelin sheath abaxonal region
GO:0042060 IGI wound healing
GO:0042734 ISS presynaptic membrane
GO:0042995 IEA cell projection
GO:0043065 ISS positive regulation of apoptotic process
GO:0043615 IEA astrocyte cell migration
GO:0045211 ISS postsynaptic membrane
GO:0045930 ISS negative regulation of mitotic cell cycle
GO:0048488 IMP synaptic vesicle endocytosis
GO:0050918 IMP positive chemotaxis
GO:0060088 IGI auditory receptor cell stereocilium organization
GO:0060561 ISS apoptotic process involved in morphogenesis
GO:0060603 IMP mammary gland duct morphogenesis
GO:0070062 IEA extracellular vesicular exosome
GO:0071896 IEA protein localization to adherens junction

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000000861 scrib scribbled homolog (Drosophila) protein_coding Danio_rerio
ENSG00000180900 SCRIB scribbled planar cell polarity protein protein_coding Homo_sapiens

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