C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: eukaryotic translation initiation factor 2-alpha kinase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000024079 Eif2ak2 10090 - 17:78852564-78882573 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000024884 Eif2ak2-001 78852564-78882573 protein_coding
  ENSMUST00000169940 Eif2ak2-004 78855354-78858980 processed_transcript
  ENSMUST00000171451 Eif2ak2-002 78878115-78882554 processed_transcript
  ENSMUST00000171852 Eif2ak2-003 78873778-78882548 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000024884ENSMUST00000171852
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000024884 2.286±0.44 1.243±0.65 2.842±0.88 0.266±0.05 1.508±0.54 1.500±0.48 0.726±0.24 1.390±0.50 1.120±0.61 1.840±0.09 0.434±0.16 2.214±2.33 4.022±1.63 0.909±0.31
ENSMUST00000171852 N/A 2.687±0.91 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000N3 CIL_0000N3_0002 CGP 17:78835516-78882573
CIL_00085G CIL_00085G_0002 VISTA 17:78844758-79446183
CIL_0000N4 CIL_0000N4_0002 CGP 17:78852564-78906992

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000186 ISS activation of MAPKK activity
GO:0001819 IMP positive regulation of cytokine production
GO:0003725 ISO double-stranded RNA binding
GO:0004672 IDA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004715 IEA non-membrane spanning protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005737 ISS cytoplasm
GO:0006351 IEA transcription, DNA-templated
GO:0006412 IDA translation
GO:0006468 IDA protein phosphorylation
GO:0009615 ISS response to virus
GO:0016020 IEA membrane
GO:0017148 ISS negative regulation of translation
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0030968 IDA endoplasmic reticulum unfolded protein response
GO:0032722 IMP positive regulation of chemokine production
GO:0032874 IMP positive regulation of stress-activated MAPK cascade
GO:0033689 ISS negative regulation of osteoblast proliferation
GO:0035455 ISS response to interferon-alpha
GO:0043066 IGI negative regulation of apoptotic process
GO:0044822 IEA poly(A) RNA binding
GO:0045071 IMP negative regulation of viral genome replication
GO:0045087 IEA innate immune response
GO:0046777 IDA protein autophosphorylation
GO:0048471 ISS perinuclear region of cytoplasm
GO:0051092 ISS positive regulation of NF-kappaB transcription factor activity
GO:0051607 IEA defense response to virus
GO:1900225 IMP regulation of NLRP3 inflammasome complex assembly
GO:1901224 IMP positive regulation of NIK/NF-kappaB signaling
GO:1901532 IMP regulation of hematopoietic progenitor cell differentiation
GO:1902033 IMP regulation of hematopoietic stem cell proliferation
GO:1902036 IMP regulation of hematopoietic stem cell differentiation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000068729 eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 protein_coding Danio_rerio
ENSG00000055332 EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 protein_coding Homo_sapiens

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