C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: heparin-binding EGF-like growth factor
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000024486 Hbegf 10090 - 18:36504929-36515805 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000025363 Hbegf-201 36504929-36515805 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000025363
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000025363 1.620±1.41 1.957±0.60 2.513±0.13 3.364±0.71 1.055±0.26 5.375±1.53 5.998±0.24 3.983±0.29 0.580±0.29 19.353±0.78 4.138±0.83 3.022±1.06 10.189±2.88 0.580±0.16

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00062T CIL_00062T_0003 CGP 18:36403679-36515805
CIL_0006ZL CIL_0006ZL_0002 CGP 18:36504929-36541293

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001525 NAS angiogenesis
GO:0001832 TAS blastocyst growth
GO:0005154 IDA epidermal growth factor receptor binding
GO:0005576 TAS extracellular region
GO:0005615 IDA extracellular space
GO:0005887 IDA integral component of plasma membrane
GO:0007173 IDA epidermal growth factor receptor signaling pathway
GO:0008016 IMP regulation of heart contraction
GO:0008083 IDA growth factor activity
GO:0008201 IDA heparin binding
GO:0009986 IEA cell surface
GO:0016477 IMP cell migration
GO:0030307 IEA positive regulation of cell growth
GO:0030335 IEA positive regulation of cell migration
GO:0035313 IMP wound healing, spreading of epidermal cells
GO:0048661 IDA positive regulation of smooth muscle cell proliferation
GO:0051545 IEA negative regulation of elastin biosynthetic process
GO:0051549 IMP positive regulation of keratinocyte migration
GO:0051897 IEA positive regulation of protein kinase B signaling
GO:0090303 IEA positive regulation of wound healing

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000031246 hbegfb heparin-binding EGF-like growth factor b protein_coding Danio_rerio
ENSDARG00000075121 hbegfa heparin-binding EGF-like growth factor a protein_coding Danio_rerio
ENSG00000113070 HBEGF heparin-binding EGF-like growth factor protein_coding Homo_sapiens

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