C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: CD28 antigen
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000026012 Cd28 10090 + 1:60716800-60773359 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000027165 Cd28-001 60746358-60773359 protein_coding
  ENSMUST00000132833 Cd28-003 60716800-60763163 processed_transcript
  ENSMUST00000153207 Cd28-002 60746402-60764626 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000027165ENSMUST00000132833ENSMUST00000153207
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000027165 0.222±0.03 0.161±0.12 0.283±0.07 0.026±0.01 3.012±1.06 0.441±0.09 0.644±0.10 0.171±0.13 0.059±0.02 0.534±0.11 0.764±0.23 0.190±0.09 0.077±0.04 0.041±0.04
ENSMUST00000132833 N/A N/A N/A N/A N/A N/A N/A 0.044±0.00 N/A N/A N/A N/A N/A N/A
ENSMUST00000153207 N/A N/A N/A N/A N/A 0.284±0.00 N/A N/A 0.107±0.03 N/A N/A 0.137±0.04 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001QX CIL_0001QX_0002 CGP 1:60482292-60773359
CIL_000398 CIL_000398_0002 CGP 1:60716800-60915832

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001772 IDA immunological synapse
GO:0002020 IEA protease binding
GO:0002863 IMP positive regulation of inflammatory response to antigenic stimulus
GO:0005070 IEA SH3/SH2 adaptor activity
GO:0005515 IEA protein binding
GO:0005886 IEA plasma membrane
GO:0006955 IEA immune response
GO:0009897 IDA external side of plasma membrane
GO:0009967 IEA positive regulation of signal transduction
GO:0014068 IDA positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016021 IEA integral component of membrane
GO:0031295 IDA T cell costimulation
GO:0042102 ISS positive regulation of T cell proliferation
GO:0045060 IMP negative thymic T cell selection
GO:0045066 IEA regulatory T cell differentiation
GO:0045086 ISS positive regulation of interleukin-2 biosynthetic process
GO:0045840 ISS positive regulation of mitosis
GO:0045944 IGI positive regulation of transcription from RNA polymerase II promoter
GO:0046641 IDA positive regulation of alpha-beta T cell proliferation
GO:0048304 IMP positive regulation of isotype switching to IgG isotypes
GO:0050852 IMP T cell receptor signaling pathway
GO:0051897 IDA positive regulation of protein kinase B signaling
GO:0097190 IDA apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSG00000178562 CD28 CD28 molecule protein_coding Homo_sapiens

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