C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: zinc finger E-box binding homeobox 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000026872 Zeb2 10090 - 2:44983634-45117395 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000028229 Zeb2-002 44987125-45110464 protein_coding
  ENSMUST00000068415 Zeb2-201 44983634-45113279 protein_coding
  ENSMUST00000076836 Zeb2-011 44988442-45112890 protein_coding
  ENSMUST00000123037 Zeb2-012 45106485-45113001 retained_intron
  ENSMUST00000124942 Zeb2-009 45104038-45113216 protein_coding
  ENSMUST00000126743 Zeb2-003 45110089-45113508 processed_transcript
  ENSMUST00000127520 Zeb2-005 45022952-45113279 protein_coding
  ENSMUST00000131635 Zeb2-008 45008598-45111076 processed_transcript
  ENSMUST00000145529 Zeb2-004 45020897-45113245 retained_intron
  ENSMUST00000152232 Zeb2-010 45104038-45110487 protein_coding
  ENSMUST00000153561 Zeb2-006 45095583-45110733 protein_coding
  ENSMUST00000176438 Zeb2-001 44983699-45117395 protein_coding
  ENSMUST00000176732 Zeb2-013 44987118-45112985 protein_coding
  ENSMUST00000177302 Zeb2-007 44988388-45110244 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000028229ENSMUST00000068415ENSMUST00000076836ENSMUST00000123037ENSMUST00000176438ENSMUST00000176732ENSMUST00000177302
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000028229 6.024±1.60 3.023±0.11 5.640±1.22 5.849±0.37 4.161±0.59 1.174±0.12 1.069±0.13 2.058±0.57 1.957±1.54 6.142±1.46 1.489±0.26 6.467±4.03 1.284±0.46 0.567±0.17
ENSMUST00000068415 N/A N/A N/A 1.799±0.00 N/A 0.434±0.04 N/A N/A N/A N/A 0.378±0.00 6.322±0.00 0.303±0.00 N/A
ENSMUST00000076836 6.161±3.04 4.316±1.05 N/A N/A 3.541±0.80 2.032±0.65 0.933±0.10 2.159±1.01 0.522±0.08 N/A N/A 5.281±1.70 N/A 0.692±0.32
ENSMUST00000123037 N/A 1.124±0.09 N/A N/A N/A 0.613±0.00 N/A N/A 0.308±0.00 N/A N/A N/A N/A N/A
ENSMUST00000176438 3.581±0.12 1.498±0.16 1.391±0.07 2.611±0.68 2.583±0.51 0.701±0.10 0.726±0.25 1.456±0.32 0.885±0.63 3.883±0.33 0.339±0.09 N/A 0.634±0.39 0.195±0.00
ENSMUST00000176732 N/A N/A N/A N/A N/A 1.637±0.20 N/A N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000177302 9.833±4.10 N/A 5.849±0.00 6.836±1.50 3.784±1.83 1.825±0.76 2.388±0.43 3.078±1.05 1.916±1.34 8.308±1.45 1.091±0.00 5.989±1.67 0.759±0.00 0.518±0.10

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007L9 CIL_0007L9_0005 UCNEbase 2:43782078-47834434
CIL_0006M9 CIL_0006M9_0002 CGP 2:44564412-45117395
CIL_0008S1 CIL_0008S1_0002 VISTA 2:44723631-45325444
CIL_0008RV CIL_0008RV_0002 VISTA 2:44736258-45337036
CIL_000944 CIL_000944_0002 VISTA 2:44802219-45404360
CIL_0008FM CIL_0008FM_0002 VISTA 2:44871143-45472955
CIL_0007GY CIL_0007GY_0002 CGP 2:44983634-48903269

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0001755 IMP neural crest cell migration
GO:0001756 IMP somitogenesis
GO:0001843 IMP neural tube closure
GO:0003676 IEA nucleic acid binding
GO:0003677 IEA DNA binding
GO:0005634 IDA nucleus
GO:0006351 IEA transcription, DNA-templated
GO:0007417 IGI central nervous system development
GO:0021766 IMP hippocampus development
GO:0021846 IMP cell proliferation in forebrain
GO:0030177 IMP positive regulation of Wnt signaling pathway
GO:0043507 IMP positive regulation of JUN kinase activity
GO:0045636 IMP positive regulation of melanocyte differentiation
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0046872 IEA metal ion binding
GO:0048023 IC positive regulation of melanin biosynthetic process
GO:0048066 IMP developmental pigmentation
GO:0048598 IGI embryonic morphogenesis
GO:0070412 IDA R-SMAD binding
GO:0097324 IMP melanocyte migration
GO:1903056 IMP regulation of melanosome organization

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000078416 zeb2b zinc finger E-box binding homeobox 2b protein_coding Danio_rerio
ENSG00000169554 ZEB2 zinc finger E-box binding homeobox 2 protein_coding Homo_sapiens

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