C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: integrin alpha 6
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000027111 Itga6 10090 + 2:71745616-71858416 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000028522 Itga6-001 71786978-71856758 protein_coding
  ENSMUST00000112101 Itga6-002 71786940-71856771 protein_coding
  ENSMUST00000126787 Itga6-005 71849029-71858416 processed_transcript
  ENSMUST00000133124 Itga6-007 71745616-71820254 processed_transcript
  ENSMUST00000139760 Itga6-009 71849437-71852635 processed_transcript
  ENSMUST00000152009 Itga6-003 71786929-71820943 processed_transcript
  ENSMUST00000155249 Itga6-004 71826762-71854951 protein_coding
  ENSMUST00000155596 Itga6-008 71838081-71838914 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000028522ENSMUST00000112101ENSMUST00000126787ENSMUST00000139760ENSMUST00000152009
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000028522 15.421±4.73 6.005±1.31 7.299±0.00 1.495±0.00 6.907±2.62 N/A 5.562±0.62 3.431±0.00 1.202±0.74 9.518±1.25 0.712±0.00 6.862±3.71 12.963±5.08 1.053±0.32
ENSMUST00000112101 5.939±0.00 9.778±2.20 N/A 2.435±1.38 3.957±0.12 6.967±0.39 2.942±0.36 11.527±2.85 0.521±0.18 6.664±1.86 1.362±0.00 2.224±0.00 4.514±1.20 0.539±0.01
ENSMUST00000126787 26.890±7.17 15.734±2.50 9.280±4.61 5.223±3.22 15.015±3.97 15.618±4.87 10.646±1.25 27.029±3.63 2.363±1.13 26.863±3.43 2.053±0.39 11.949±4.80 13.102±2.81 1.666±0.50
ENSMUST00000139760 N/A 56.941±9.11 N/A N/A N/A N/A 86.979±43.81 N/A N/A N/A N/A 61.163±33.12 N/A 7.054±0.84
ENSMUST00000152009 N/A 28.780±11.04 N/A N/A 11.911±1.27 28.245±4.82 N/A N/A 0.633±0.00 13.310±0.00 N/A 20.098±2.85 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008C9 CIL_0008C9_0002 VISTA 2:71216484-71818219
CIL_0009AY CIL_0009AY_0002 VISTA 2:71227336-71828847
CIL_0008AZ CIL_0008AZ_0002 VISTA 2:71235378-71836557
CIL_0008B0 CIL_0008B0_0002 VISTA 2:71237156-71838581
CIL_0003IK CIL_0003IK_0003 CGP 2:71543408-71858416
CIL_0004K8 CIL_0004K8_0002 CGP 2:71745616-71903858

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005178 IPI integrin binding
GO:0005515 IEA protein binding
GO:0005604 IDA basement membrane
GO:0005886 IDA plasma membrane
GO:0005913 IEA cell-cell adherens junction
GO:0005925 IEA focal adhesion
GO:0007160 IMP cell-matrix adhesion
GO:0007229 IEA integrin-mediated signaling pathway
GO:0008305 IDA integrin complex
GO:0009897 IDA external side of plasma membrane
GO:0009925 IDA basal plasma membrane
GO:0009986 IDA cell surface
GO:0010668 IEA ectodermal cell differentiation
GO:0010811 IEA positive regulation of cell-substrate adhesion
GO:0016323 IDA basolateral plasma membrane
GO:0016337 IEA single organismal cell-cell adhesion
GO:0022409 IDA positive regulation of cell-cell adhesion
GO:0030056 IDA hemidesmosome
GO:0030175 IEA filopodium
GO:0031589 IEA cell-substrate adhesion
GO:0031668 IDA cellular response to extracellular stimulus
GO:0032403 IEA protein complex binding
GO:0033627 IDA cell adhesion mediated by integrin
GO:0034676 IEA integrin alpha6-beta4 complex
GO:0035878 IEA nail development
GO:0042327 IEA positive regulation of phosphorylation
GO:0042475 IMP odontogenesis of dentin-containing tooth
GO:0043065 IEA positive regulation of apoptotic process
GO:0043236 IEA laminin binding
GO:0043588 IEA skin development
GO:0045178 IDA basal part of cell
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0046847 IMP filopodium assembly
GO:0046872 IEA metal ion binding
GO:0048565 IEA digestive tract development
GO:0050873 IDA brown fat cell differentiation
GO:0050900 IMP leukocyte migration
GO:0071407 IEA cellular response to organic cyclic compound
GO:0072001 IEA renal system development
GO:0097186 IEA amelogenesis
GO:2001237 IEA negative regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000042282 itga6a integrin, alpha 6a protein_coding Danio_rerio
ENSDARG00000056018 itga6l integrin, alpha 6, like protein_coding Danio_rerio
ENSDARG00000069946 itga6b integrin, alpha 6b protein_coding Danio_rerio
ENSG00000091409 ITGA6 integrin, alpha 6 protein_coding Homo_sapiens

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