C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: paired-like homeodomain transcription factor 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000028023 Pitx2 10090 + 3:129199878-129219591 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000029657 Pitx2-005 129199922-129219578 protein_coding
  ENSMUST00000042587 Pitx2-003 129213972-129219588 protein_coding
  ENSMUST00000106382 Pitx2-001 129199926-129219591 protein_coding
  ENSMUST00000172645 Pitx2-006 129203947-129218897 protein_coding
  ENSMUST00000173645 Pitx2-008 129199969-129204577 protein_coding
  ENSMUST00000174623 Pitx2-004 129214275-129216624 protein_coding
  ENSMUST00000174661 Pitx2-002 129199878-129219590 protein_coding
  ENSMUST00000187145 Pitx2-007 129213932-129216774 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000029657ENSMUST00000042587ENSMUST00000106382ENSMUST00000172645ENSMUST00000174623ENSMUST00000174661ENSMUST00000187145
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000029657 N/A N/A N/A N/A N/A 0.036±0.00 N/A N/A N/A 0.150±0.00 N/A 0.069±0.00 1.442±0.48 N/A
ENSMUST00000042587 N/A 0.047±0.01 10.616±1.00 1.121±0.57 0.540±0.07 N/A 0.248±0.06 1.790±0.26 0.163±0.17 0.396±0.11 1.232±0.22 0.112±0.07 2.283±1.02 N/A
ENSMUST00000106382 N/A 0.082±0.01 13.526±0.71 1.269±0.67 0.509±0.04 N/A N/A N/A 0.259±0.34 0.226±0.07 1.122±0.41 0.085±0.00 2.506±1.28 0.948±0.36
ENSMUST00000172645 0.086±0.00 0.095±0.07 11.482±0.45 3.344±0.32 1.448±0.35 0.055±0.00 0.623±0.31 2.264±1.04 0.281±0.19 0.299±0.12 1.686±0.35 0.069±0.02 3.780±0.37 1.718±0.59
ENSMUST00000174623 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.137±0.00 N/A N/A
ENSMUST00000174661 N/A N/A N/A N/A N/A N/A N/A N/A 0.342±0.00 N/A 0.436±0.00 N/A N/A N/A
ENSMUST00000187145 0.043±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.017±0.00 N/A 0.132±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007P9 CIL_0007P9_0002 UCNEbase 3:127625906-129219414
CIL_0007RD CIL_0007RD_0002 VISTA 3:128625921-129227117
CIL_0007ZJ CIL_0007ZJ_0002 VISTA 3:128803805-129405710
CIL_000912 CIL_000912_0002 VISTA 3:128878432-129478935
CIL_000917 CIL_000917_0002 VISTA 3:128927194-129527766

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0000976 IEA transcription regulatory region sequence-specific DNA binding
GO:0000978 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 IDA sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001085 IEA RNA polymerase II transcription factor binding
GO:0001102 IEA RNA polymerase II activating transcription factor binding
GO:0001105 IEA RNA polymerase II transcription coactivator activity
GO:0001191 IEA RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription
GO:0001569 IMP patterning of blood vessels
GO:0001570 IMP vasculogenesis
GO:0001701 IMP in utero embryonic development
GO:0001764 IMP neuron migration
GO:0002074 IMP extraocular skeletal muscle development
GO:0003171 IMP atrioventricular valve development
GO:0003253 IMP cardiac neural crest cell migration involved in outflow tract morphogenesis
GO:0003350 IMP pulmonary myocardium development
GO:0003677 IDA DNA binding
GO:0003682 IDA chromatin binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005667 IDA transcription factor complex
GO:0005737 IDA cytoplasm
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0006357 IGI regulation of transcription from RNA polymerase II promoter
GO:0006366 IDA transcription from RNA polymerase II promoter
GO:0007368 IMP determination of left/right symmetry
GO:0007420 IEA brain development
GO:0007507 IMP heart development
GO:0007519 IMP skeletal muscle tissue development
GO:0007520 IDA myoblast fusion
GO:0008134 IEA transcription factor binding
GO:0008584 IEA male gonad development
GO:0008585 IEA female gonad development
GO:0009653 IMP anatomical structure morphogenesis
GO:0009725 IEA response to hormone
GO:0009887 IMP organ morphogenesis
GO:0016055 IDA Wnt signaling pathway
GO:0021763 IMP subthalamic nucleus development
GO:0021855 IMP hypothalamus cell migration
GO:0021983 IMP pituitary gland development
GO:0030182 IEA neuron differentiation
GO:0030324 IMP lung development
GO:0030334 IMP regulation of cell migration
GO:0031076 IMP embryonic camera-type eye development
GO:0031490 IDA chromatin DNA binding
GO:0033189 IEA response to vitamin A
GO:0035116 IGI embryonic hindlimb morphogenesis
GO:0035886 IMP vascular smooth muscle cell differentiation
GO:0035993 IMP deltoid tuberosity development
GO:0042127 IMP regulation of cell proliferation
GO:0042475 IEA odontogenesis of dentin-containing tooth
GO:0042476 IMP odontogenesis
GO:0042803 IEA protein homodimerization activity
GO:0043010 IEA camera-type eye development
GO:0043388 IDA positive regulation of DNA binding
GO:0043565 IDA sequence-specific DNA binding
GO:0045893 IMP positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0048536 IMP spleen development
GO:0048557 IMP embryonic digestive tract morphogenesis
GO:0048738 IMP cardiac muscle tissue development
GO:0051219 IEA phosphoprotein binding
GO:0055007 IMP cardiac muscle cell differentiation
GO:0055009 IMP atrial cardiac muscle tissue morphogenesis
GO:0055015 IMP ventricular cardiac muscle cell development
GO:0055123 IMP digestive system development
GO:0060412 IMP ventricular septum morphogenesis
GO:0060460 IMP left lung morphogenesis
GO:0060577 IMP pulmonary vein morphogenesis
GO:0060578 IMP superior vena cava morphogenesis
GO:0061031 IMP endodermal digestive tract morphogenesis
GO:0061072 IEA iris morphogenesis
GO:0061325 IMP cell proliferation involved in outflow tract morphogenesis
GO:0070986 IMP left/right axis specification
GO:2000288 IDA positive regulation of myoblast proliferation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSG00000164093 PITX2 paired-like homeodomain 2 protein_coding Homo_sapiens

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