C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: lamin A
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000028063 Lmna 10090 - 3:88481148-88509956 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000029699 Lmna-001 88481148-88503335 protein_coding
  ENSMUST00000036252 Lmna-003 88483206-88493312 protein_coding
  ENSMUST00000120377 Lmna-002 88483205-88503307 protein_coding
  ENSMUST00000135494 Lmna-005 88481846-88503337 processed_transcript
  ENSMUST00000147537 Lmna-006 88483206-88484607 retained_intron
  ENSMUST00000149068 Lmna-004 88502753-88509956 protein_coding
  ENSMUST00000150496 Lmna-007 88482077-88482864 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000029699ENSMUST00000036252ENSMUST00000120377ENSMUST00000135494ENSMUST00000149068
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000029699 27.496±5.83 16.134±1.91 43.376±2.25 2.921±0.18 24.648±11.04 89.661±13.80 9.122±2.53 9.535±1.61 8.257±2.09 27.754±2.45 5.889±1.87 25.943±8.99 17.371±4.10 0.729±0.00
ENSMUST00000036252 N/A N/A N/A 41.745±0.00 N/A N/A N/A N/A N/A N/A N/A 47.585±29.98 89.660±11.21 8.778±6.80
ENSMUST00000120377 36.694±1.36 14.780±2.71 43.586±4.92 12.079±5.90 27.351±1.53 66.476±14.62 22.275±3.65 14.465±1.37 25.764±21.55 40.833±6.05 15.769±1.68 35.797±8.82 39.431±7.43 1.877±0.45
ENSMUST00000135494 N/A N/A N/A N/A 25.112±0.70 85.713±8.34 N/A N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000149068 40.982±2.56 72.353±22.56 N/A N/A 76.381±18.66 186.067±35.32 N/A 15.095±0.71 N/A 46.740±9.84 N/A 101.344±16.39 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008P5 CIL_0008P5_0002 VISTA 3:88218217-88823366
CIL_000898 CIL_000898_0002 VISTA 3:88224783-88827970

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005198 IEA structural molecule activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005635 IDA nuclear envelope
GO:0005638 IDA lamin filament
GO:0005737 IEA cytoplasm
GO:0006997 IMP nucleus organization
GO:0006998 IGI nuclear envelope organization
GO:0007517 ISS muscle organ development
GO:0030010 NAS establishment of cell polarity
GO:0030334 IMP regulation of cell migration
GO:0030951 IMP establishment or maintenance of microtubule cytoskeleton polarity
GO:0034504 IMP protein localization to nucleus
GO:0035105 IMP sterol regulatory element binding protein import into nucleus
GO:0048471 ISS perinuclear region of cytoplasm
GO:0055015 IMP ventricular cardiac muscle cell development
GO:0071456 ISS cellular response to hypoxia
GO:0090201 IMP negative regulation of release of cytochrome c from mitochondria
GO:0090343 ISS positive regulation of cell aging
GO:1900180 IMP regulation of protein localization to nucleus
GO:2001237 IMP negative regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000013415 lmna lamin A protein_coding Danio_rerio
ENSG00000160789 LMNA lamin A/C protein_coding Homo_sapiens

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