C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000028064 Sema4a 10090 - 3:88435959-88461182 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000029700 Sema4a-001 88435959-88455739 protein_coding
  ENSMUST00000107531 Sema4a-002 88435962-88455697 protein_coding
  ENSMUST00000123753 Sema4a-010 88454765-88456436 protein_coding
  ENSMUST00000125526 Sema4a-011 88452044-88455305 protein_coding
  ENSMUST00000127436 Sema4a-004 88450097-88459101 protein_coding
  ENSMUST00000135539 Sema4a-015 88435962-88448630 retained_intron
  ENSMUST00000135732 Sema4a-006 88449824-88451786 retained_intron
  ENSMUST00000141471 Sema4a-003 88453089-88456415 protein_coding
  ENSMUST00000146921 Sema4a-012 88455725-88456436 processed_transcript
  ENSMUST00000147200 Sema4a-005 88450585-88458876 protein_coding
  ENSMUST00000149145 Sema4a-014 88435962-88450038 retained_intron
  ENSMUST00000156108 Sema4a-016 88435962-88441139 retained_intron
  ENSMUST00000165898 Sema4a-201 88435962-88459101 protein_coding
  ENSMUST00000166237 Sema4a-202 88435962-88461182 protein_coding
  ENSMUST00000169222 Sema4a-203 88435962-88458884 protein_coding
  ENSMUST00000184487 Sema4a-008 88450035-88455314 nonsense_mediated_decay
  ENSMUST00000184876 Sema4a-009 88450568-88459030 nonsense_mediated_decay
  ENSMUST00000184972 Sema4a-013 88452831-88454842 retained_intron
  ENSMUST00000185137 Sema4a-007 88449686-88451450 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000029700ENSMUST00000107531ENSMUST00000135539ENSMUST00000135732ENSMUST00000149145ENSMUST00000156108ENSMUST00000165898ENSMUST00000166237ENSMUST00000169222ENSMUST00000184487
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000029700 4.584±1.57 3.219±0.27 19.697±4.66 3.707±0.00 11.531±2.08 72.386±22.00 0.477±0.21 43.074±11.74 19.758±16.54 15.735±2.51 0.486±0.00 6.154±2.40 3.739±3.50 N/A
ENSMUST00000107531 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.191±0.09 0.807±0.00 N/A N/A
ENSMUST00000135539 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.123±0.01 N/A N/A N/A
ENSMUST00000135732 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.384±0.00 N/A N/A N/A
ENSMUST00000149145 2.772±0.00 2.309±0.18 4.840±0.00 6.371±3.75 7.484±1.26 20.363±1.27 0.602±0.12 N/A N/A 4.337±1.41 0.303±0.06 2.907±0.94 0.365±0.09 1.608±0.00
ENSMUST00000156108 7.378±2.71 12.219±3.36 N/A N/A 15.780±2.08 N/A 0.619±0.16 N/A N/A N/A 0.295±0.07 4.124±0.83 N/A N/A
ENSMUST00000165898 N/A N/A N/A 5.550±0.91 N/A N/A N/A N/A N/A N/A N/A N/A N/A 12.103±6.35
ENSMUST00000166237 5.337±0.00 N/A 3.342±0.00 N/A 8.831±0.00 N/A 0.605±0.00 18.156±1.12 6.311±1.14 N/A 0.310±0.14 2.861±0.68 5.185±4.15 3.933±1.83
ENSMUST00000169222 1.976±0.00 N/A N/A 3.217±0.05 5.044±2.24 N/A 0.910±0.17 N/A N/A N/A N/A 2.756±0.11 N/A 3.944±0.00
ENSMUST00000184487 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.463±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008JO CIL_0008JO_0002 VISTA 3:87838105-88441065
CIL_0008P5 CIL_0008P5_0002 VISTA 3:88218217-88823366
CIL_000898 CIL_000898_0002 VISTA 3:88224783-88827970

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001525 IEA angiogenesis
GO:0002292 IMP T cell differentiation involved in immune response
GO:0004872 IEA receptor activity
GO:0005886 IEA plasma membrane
GO:0007275 IEA multicellular organismal development
GO:0007409 IMP axonogenesis
GO:0008360 IDA regulation of cell shape
GO:0010594 IMP regulation of endothelial cell migration
GO:0016021 IEA integral component of membrane
GO:0016525 IMP negative regulation of angiogenesis
GO:0045063 IMP T-helper 1 cell differentiation
GO:0071526 IMP semaphorin-plexin signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000062352 sema4ab sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Ab protein_coding Danio_rerio
ENSDARG00000077103 sema4aa sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Aa protein_coding Danio_rerio
ENSG00000196189 SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A protein_coding Homo_sapiens

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