C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: purinergic receptor P2X, ligand-gated ion channel 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000029470 P2rx4 10090 + 5:122707584-122729738 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000031429 P2rx4-001 122707584-122729738 protein_coding
  ENSMUST00000081554 P2rx4-002 122707584-122729044 protein_coding
  ENSMUST00000132062 P2rx4-006 122724655-122725265 retained_intron
  ENSMUST00000139631 P2rx4-003 122707654-122727840 protein_coding
  ENSMUST00000139712 P2rx4-007 122727664-122728585 processed_transcript
  ENSMUST00000142664 P2rx4-004 122707654-122727840 protein_coding
  ENSMUST00000152337 P2rx4-005 122707612-122719477 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000031429ENSMUST00000081554ENSMUST00000142664
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000031429 N/A N/A N/A 0.631±0.15 N/A N/A 1.417±0.00 N/A 1.424±0.35 N/A 0.374±0.03 4.747±1.56 1.370±0.61 0.659±0.25
ENSMUST00000081554 29.355±2.33 18.033±4.20 13.713±0.84 3.257±1.46 32.942±7.38 93.035±17.71 9.127±2.99 30.169±2.26 13.530±6.41 41.539±0.98 1.303±0.38 16.201±4.22 12.953±5.84 2.616±0.65
ENSMUST00000142664 15.202±0.75 N/A 7.756±1.03 2.511±1.69 10.886±0.40 28.530±0.00 2.992±0.16 10.910±1.01 7.503±0.52 16.371±0.37 0.674±0.09 6.557±1.46 8.129±4.52 1.208±0.16

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002ZL CIL_0002ZL_0002 CGP 5:122643911-122729738
CIL_0002ZK CIL_0002ZK_0002 CGP 5:122707584-122779410

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001614 IBA purinergic nucleotide receptor activity
GO:0002028 IEA regulation of sodium ion transport
GO:0004931 IMP extracellular ATP-gated cation channel activity
GO:0005102 IEA receptor binding
GO:0005507 IEA copper ion binding
GO:0005515 IEA protein binding
GO:0005524 IEA ATP binding
GO:0005639 IBA integral component of nuclear inner membrane
GO:0005765 IEA lysosomal membrane
GO:0005886 IEA plasma membrane
GO:0005887 ISS integral component of plasma membrane
GO:0006809 IDA nitric oxide biosynthetic process
GO:0006810 IEA transport
GO:0006816 IMP calcium ion transport
GO:0007165 IEA signal transduction
GO:0008144 IEA drug binding
GO:0008217 IEA regulation of blood pressure
GO:0008270 IEA zinc ion binding
GO:0010524 IEA positive regulation of calcium ion transport into cytosol
GO:0010614 IEA negative regulation of cardiac muscle hypertrophy
GO:0014069 IEA postsynaptic density
GO:0019228 IEA neuronal action potential
GO:0019233 IEA sensory perception of pain
GO:0030054 IEA cell junction
GO:0030424 IEA axon
GO:0030425 IEA dendrite
GO:0033198 IEA response to ATP
GO:0034220 IEA ion transmembrane transport
GO:0034405 IEA response to fluid shear stress
GO:0035590 IEA purinergic nucleotide receptor signaling pathway
GO:0042311 IMP vasodilation
GO:0043025 IEA neuronal cell body
GO:0043195 IEA terminal bouton
GO:0043197 IEA dendritic spine
GO:0045177 IDA apical part of cell
GO:0045202 IEA synapse
GO:0045296 IEA cadherin binding
GO:0048471 IEA perinuclear region of cytoplasm
GO:0050850 IEA positive regulation of calcium-mediated signaling
GO:0051260 IEA protein homooligomerization
GO:0051899 IEA membrane depolarization
GO:0055117 IEA regulation of cardiac muscle contraction
GO:0055119 IEA relaxation of cardiac muscle
GO:0060079 IMP regulation of excitatory postsynaptic membrane potential
GO:0070062 IEA extracellular vesicular exosome
GO:0071318 IEA cellular response to ATP
GO:0097190 IEA apoptotic signaling pathway
GO:0098655 IMP cation transmembrane transport

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000042452 p2rx4b purinergic receptor P2X, ligand-gated ion channel, 4b protein_coding Danio_rerio
ENSDARG00000044752 p2rx4a purinergic receptor P2X, ligand-gated ion channel, 4a protein_coding Danio_rerio
ENSG00000135124 P2RX4 purinergic receptor P2X, ligand-gated ion channel, 4 protein_coding Homo_sapiens

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