C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: enhancer of zeste homolog 2 (Drosophila)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000029687 Ezh2 10090 - 6:47530274-47595341 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000081721 Ezh2-001 47530274-47595030 protein_coding
  ENSMUST00000092648 Ezh2-010 47530541-47577660 protein_coding
  ENSMUST00000114616 Ezh2-004 47530274-47595030 protein_coding
  ENSMUST00000114618 Ezh2-003 47530274-47595030 protein_coding
  ENSMUST00000133043 Ezh2-002 47552386-47595341 protein_coding
  ENSMUST00000164006 Ezh2-008 47540843-47551761 nonsense_mediated_decay
  ENSMUST00000165492 Ezh2-009 47533742-47545883 retained_intron
  ENSMUST00000167278 Ezh2-007 47544006-47551761 nonsense_mediated_decay
  ENSMUST00000169889 Ezh2-006 47545783-47554214 nonsense_mediated_decay
  ENSMUST00000170311 Ezh2-011 47532630-47540709 retained_intron
  ENSMUST00000170327 Ezh2-005 47556027-47578010 retained_intron
  ENSMUST00000171614 Ezh2-012 47532010-47535125 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000081721ENSMUST00000092648ENSMUST00000114616ENSMUST00000114618ENSMUST00000133043ENSMUST00000164006ENSMUST00000165492ENSMUST00000167278ENSMUST00000171614
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000081721 1.582±0.67 0.357±0.13 4.223±0.75 23.338±5.08 1.406±0.24 0.817±0.21 0.548±0.24 0.871±0.23 11.582±10.91 1.111±0.35 0.767±0.16 2.080±2.03 10.314±6.51 N/A
ENSMUST00000092648 0.516±0.00 0.239±0.10 N/A 12.031±2.87 N/A 0.791±0.00 0.572±0.01 0.630±0.00 6.551±5.88 N/A N/A 2.213±1.26 4.935±1.90 6.972±0.68
ENSMUST00000114616 1.605±0.00 0.359±0.14 N/A 0.542±0.00 N/A N/A 0.221±0.00 0.400±0.11 0.514±0.20 0.403±0.00 N/A 6.405±0.00 N/A 7.004±0.00
ENSMUST00000114618 N/A N/A N/A N/A N/A 0.573±0.00 N/A 0.321±0.00 N/A N/A 0.419±0.07 0.902±0.54 N/A N/A
ENSMUST00000133043 N/A N/A N/A 1.824±0.00 N/A N/A N/A N/A N/A N/A N/A 15.021±0.00 22.287±16.30 43.733±0.00
ENSMUST00000164006 N/A 0.495±0.07 N/A 4.624±0.00 N/A N/A N/A N/A 0.570±0.00 N/A N/A 44.708±0.00 60.570±39.57 203.576±0.00
ENSMUST00000165492 1.238±0.53 0.380±0.16 3.235±0.00 7.474±7.03 0.962±0.24 1.389±0.51 0.263±0.06 0.406±0.05 2.421±2.30 0.505±0.00 0.226±0.00 1.874±0.86 N/A N/A
ENSMUST00000167278 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 48.383±0.00 49.502±0.00
ENSMUST00000171614 N/A 0.260±0.10 N/A N/A 0.787±0.10 1.028±0.14 0.421±0.00 0.441±0.01 N/A N/A N/A 1.115±0.45 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004XU CIL_0004XU_0002 CGP 6:47453398-47595341
CIL_0004XT CIL_0004XT_0002 CGP 6:47530274-47813512

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 ISS negative regulation of transcription from RNA polymerase II promoter
GO:0000790 IDA nuclear chromatin
GO:0000975 IEA regulatory region DNA binding
GO:0001047 IMP core promoter binding
GO:0001932 IMP regulation of protein phosphorylation
GO:0003682 IDA chromatin binding
GO:0003723 IPI RNA binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IEA cytoplasm
GO:0006306 IMP DNA methylation
GO:0006351 IEA transcription, DNA-templated
GO:0006357 IMP regulation of transcription from RNA polymerase II promoter
GO:0010468 IMP regulation of gene expression
GO:0010629 IEA negative regulation of gene expression
GO:0010718 ISS positive regulation of epithelial to mesenchymal transition
GO:0014013 IMP regulation of gliogenesis
GO:0014834 IMP skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
GO:0016571 IDA histone methylation
GO:0018024 IEA histone-lysine N-methyltransferase activity
GO:0021695 IMP cerebellar cortex development
GO:0031490 IEA chromatin DNA binding
GO:0032320 ISS positive regulation of Ras GTPase activity
GO:0034244 IMP negative regulation of transcription elongation from RNA polymerase II promoter
GO:0035098 IDA ESC/E(Z) complex
GO:0042054 IDA histone methyltransferase activity
GO:0042127 IMP regulation of cell proliferation
GO:0042752 IMP regulation of circadian rhythm
GO:0043406 ISS positive regulation of MAP kinase activity
GO:0043565 IDA sequence-specific DNA binding
GO:0045120 IDA pronucleus
GO:0045605 IMP negative regulation of epidermal cell differentiation
GO:0045814 ISS negative regulation of gene expression, epigenetic
GO:0045892 ISS negative regulation of transcription, DNA-templated
GO:0048387 ISS negative regulation of retinoic acid receptor signaling pathway
GO:0050767 IMP regulation of neurogenesis
GO:0051154 IDA negative regulation of striated muscle cell differentiation
GO:0070301 IDA cellular response to hydrogen peroxide
GO:0070314 IMP G1 to G0 transition
GO:0070734 IMP histone H3-K27 methylation
GO:0071168 IMP protein localization to chromatin
GO:0071902 ISS positive regulation of protein serine/threonine kinase activity
GO:2000134 IMP negative regulation of G1/S transition of mitotic cell cycle

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000010571 ezh2 enhancer of zeste homolog 2 (Drosophila) protein_coding Danio_rerio
ENSG00000106462 EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit protein_coding Homo_sapiens

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