C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: phosphodiesterase 3B, cGMP-inhibited
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000030671 Pde3b 10090 + 7:114415281-114539251 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000032909 Pde3b-001 114415281-114539251 protein_coding
  ENSMUST00000140007 Pde3b-002 114506178-114508463 retained_intron
  ENSMUST00000149455 Pde3b-003 114521734-114531022 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000032909ENSMUST00000149455
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000032909 9.635±3.37 2.680±1.56 4.034±3.15 0.470±0.18 9.840±4.73 0.866±0.12 0.776±0.40 1.998±0.43 4.395±1.93 1.511±0.18 0.441±0.16 1.737±1.39 0.143±0.08 4.901±0.85
ENSMUST00000149455 19.237±0.00 N/A N/A N/A 17.428±4.41 N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003ZT CIL_0003ZT_0002 CGP 7:114264606-114539251
CIL_0003ZS CIL_0003ZS_0002 CGP 7:114415281-114562972

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004114 IEA 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0005515 IEA protein binding
GO:0006198 IEA cAMP catabolic process
GO:0007162 IEA negative regulation of cell adhesion
GO:0007165 IEA signal transduction
GO:0016020 IEA membrane
GO:0016525 IEA negative regulation of angiogenesis
GO:0031018 IDA endocrine pancreas development
GO:0032045 IEA guanyl-nucleotide exchange factor complex
GO:0042593 IDA glucose homeostasis
GO:0046872 IEA metal ion binding
GO:0050796 IDA regulation of insulin secretion
GO:0050995 IEA negative regulation of lipid catabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000062190 PDE3B phosphodiesterase 3B, cGMP-inhibited protein_coding Danio_rerio
ENSG00000152270 PDE3B phosphodiesterase 3B, cGMP-inhibited protein_coding Homo_sapiens

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