C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: apolipoprotein C-III
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000032081 Apoc3 10090 - 9:46232933-46235636 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000034586 Apoc3-001 46233051-46235299 protein_coding
  ENSMUST00000118649 Apoc3-002 46233198-46235636 protein_coding
  ENSMUST00000121916 Apoc3-003 46232933-46235260 protein_coding
  ENSMUST00000145672 Apoc3-004 46234437-46235469 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000034586ENSMUST00000118649ENSMUST00000121916ENSMUST00000145672
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000034586 3.283±1.42 3.499±0.43 0.212±0.06 N/A 15.271±8.91 0.794±0.42 0.786±0.23 18.616±1.70 2292.351±2271.02 1.257±0.23 0.831±0.00 6.721±4.27 5.556±5.85 0.161±0.08
ENSMUST00000118649 N/A N/A N/A 0.074±0.00 N/A 0.683±0.00 0.273±0.00 N/A 1.158±0.34 0.182±0.00 0.202±0.00 1.384±0.63 5.525±4.04 N/A
ENSMUST00000121916 N/A 0.265±0.03 N/A N/A 0.981±0.00 N/A N/A N/A N/A N/A N/A 0.494±0.03 N/A N/A
ENSMUST00000145672 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.739±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007RC CIL_0007RC_0002 VISTA 9:45818249-46421546
CIL_0008EK CIL_0008EK_0002 VISTA 9:46081147-46681838

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005543 IEA phospholipid binding
GO:0005576 TAS extracellular region
GO:0005615 IEA extracellular space
GO:0005829 TAS cytosol
GO:0006641 IMP triglyceride metabolic process
GO:0006642 IMP triglyceride mobilization
GO:0006869 IEA lipid transport
GO:0006954 IEA inflammatory response
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0007584 IEA response to nutrient
GO:0008203 IMP cholesterol metabolic process
GO:0008289 IEA lipid binding
GO:0010897 IEA negative regulation of triglyceride catabolic process
GO:0010916 IEA negative regulation of very-low-density lipoprotein particle clearance
GO:0010987 IEA negative regulation of high-density lipoprotein particle clearance
GO:0010989 IEA negative regulation of low-density lipoprotein particle clearance
GO:0019433 IMP triglyceride catabolic process
GO:0030234 IEA enzyme regulator activity
GO:0032489 IEA regulation of Cdc42 protein signal transduction
GO:0033344 IEA cholesterol efflux
GO:0033700 IEA phospholipid efflux
GO:0034361 IEA very-low-density lipoprotein particle
GO:0034363 IEA intermediate-density lipoprotein particle
GO:0034366 IEA spherical high-density lipoprotein particle
GO:0034375 IEA high-density lipoprotein particle remodeling
GO:0034382 IEA chylomicron remnant clearance
GO:0042157 IEA lipoprotein metabolic process
GO:0042493 IEA response to drug
GO:0042627 IEA chylomicron
GO:0042632 IEA cholesterol homeostasis
GO:0042953 IEA lipoprotein transport
GO:0043434 IEA response to peptide hormone
GO:0045717 IEA negative regulation of fatty acid biosynthetic process
GO:0045833 IEA negative regulation of lipid metabolic process
GO:0048261 IEA negative regulation of receptor-mediated endocytosis
GO:0050995 IEA negative regulation of lipid catabolic process
GO:0051005 IEA negative regulation of lipoprotein lipase activity
GO:0055102 IEA lipase inhibitor activity
GO:0060621 IEA negative regulation of cholesterol import
GO:0070062 IEA extracellular vesicular exosome
GO:0070328 IEA triglyceride homeostasis
GO:0070653 IEA high-density lipoprotein particle receptor binding
GO:0071333 IEA cellular response to glucose stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSG00000110245 APOC3 apolipoprotein C-III protein_coding Homo_sapiens

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