C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: gamma-aminobutyric acid (GABA) A receptor, subunit beta 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000033676 Gabrb3 10090 + 7:57590518-57828802 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000039697 Gabrb3-001 57591162-57828802 protein_coding
  ENSMUST00000085240 Gabrb3-002 57590518-57828802 protein_coding
  ENSMUST00000136033 Gabrb3-005 57792128-57816315 retained_intron
  ENSMUST00000138350 Gabrb3-004 57591530-57816370 protein_coding
  ENSMUST00000156375 Gabrb3-003 57591162-57765781 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000039697ENSMUST00000085240ENSMUST00000136033ENSMUST00000138350ENSMUST00000156375
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000039697 0.077±0.10 0.408±0.22 0.069±0.03 12.873±2.81 0.008±0.01 0.119±0.03 0.013±0.01 2.187±0.32 0.039±0.02 0.062±0.00 0.006±0.00 0.125±0.05 0.025±0.01 0.199±0.02
ENSMUST00000085240 0.070±0.09 N/A 0.081±0.00 4.156±0.43 0.015±0.01 0.145±0.02 0.033±0.02 0.402±0.00 0.034±0.02 0.019±0.00 0.006±0.00 0.129±0.04 0.045±0.02 0.092±0.01
ENSMUST00000136033 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.247±0.06 0.088±0.00 N/A
ENSMUST00000138350 N/A 0.677±0.09 N/A N/A N/A 0.163±0.00 N/A N/A 0.324±0.10 N/A N/A 0.460±0.00 N/A 0.903±0.00
ENSMUST00000156375 0.653±0.00 1.620±0.29 N/A N/A N/A 0.220±0.05 N/A 1.553±0.00 0.136±0.00 0.057±0.01 N/A 0.427±0.21 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006LH CIL_0006LH_0002 CGP 7:57407690-57828802
CIL_0007CV CIL_0007CV_0002 CGP 7:57590518-58829426

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004890 ISS GABA-A receptor activity
GO:0005230 IEA extracellular ligand-gated ion channel activity
GO:0005254 IEA chloride channel activity
GO:0005886 IDA plasma membrane
GO:0005887 ISS integral component of plasma membrane
GO:0007214 ISO gamma-aminobutyric acid signaling pathway
GO:0007605 IMP sensory perception of sound
GO:0016021 IEA integral component of membrane
GO:0022851 ISS GABA-gated chloride ion channel activity
GO:0030054 IEA cell junction
GO:0034220 IEA ion transmembrane transport
GO:0034707 IEA chloride channel complex
GO:0043523 IMP regulation of neuron apoptotic process
GO:0043524 IMP negative regulation of neuron apoptotic process
GO:0045202 IEA synapse
GO:0045211 IEA postsynaptic membrane
GO:0048666 IMP neuron development
GO:0060021 IMP palate development
GO:0060119 IMP inner ear receptor cell development
GO:0060384 IMP innervation
GO:0071420 ISS cellular response to histamine
GO:0090102 IMP cochlea development
GO:1901215 IMP negative regulation of neuron death
GO:1902476 ISS chloride transmembrane transport
GO:1902711 ISS GABA-A receptor complex

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000023771 gabrb3 gamma-aminobutyric acid (GABA) A receptor, beta 3 protein_coding Danio_rerio
ENSG00000166206 GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 protein_coding Homo_sapiens

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