C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: sine oculis-related homeobox 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000034460 Six4 10090 - 12:73099609-73113456 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000043208 Six4-001 73099609-73113425 protein_coding
  ENSMUST00000175693 Six4-002 73103441-73113456 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000043208ENSMUST00000175693
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000043208 0.344±0.22 0.143±0.05 0.379±0.01 0.073±0.00 N/A 0.118±0.04 0.323±0.00 0.248±0.20 0.010±0.00 0.514±0.23 0.596±0.19 0.842±0.05 0.092±0.08 0.029±0.00
ENSMUST00000175693 0.106±0.07 0.103±0.04 N/A 0.044±0.02 0.168±0.00 0.079±0.04 N/A 0.072±0.00 0.007±0.00 0.265±0.04 N/A 0.420±0.19 0.023±0.01 0.031±0.01

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008MW CIL_0008MW_0002 VISTA 12:72750612-73352572
CIL_0006SM CIL_0006SM_0003 CGP 12:73040015-73113456
CIL_0006SL CIL_0006SL_0003 CGP 12:73099609-73273988

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003677 IDA DNA binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IC nucleus
GO:0005737 IDA cytoplasm
GO:0007519 IGI skeletal muscle tissue development
GO:0008582 IGI regulation of synaptic growth at neuromuscular junction
GO:0008584 IMP male gonad development
GO:0010468 IGI regulation of gene expression
GO:0030238 IMP male sex determination
GO:0030910 IMP olfactory placode formation
GO:0032880 IGI regulation of protein localization
GO:0042472 IGI inner ear morphogenesis
GO:0043524 IMP negative regulation of neuron apoptotic process
GO:0043565 IDA sequence-specific DNA binding
GO:0043586 IMP tongue development
GO:0045214 IMP sarcomere organization
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046661 IMP male sex differentiation
GO:0048538 IGI thymus development
GO:0048699 IMP generation of neurons
GO:0048701 IGI embryonic cranial skeleton morphogenesis
GO:0048704 IGI embryonic skeletal system morphogenesis
GO:0048856 IGI anatomical structure development
GO:0050678 IMP regulation of epithelial cell proliferation
GO:0051451 IGI myoblast migration
GO:0060037 IMP pharyngeal system development
GO:0061055 IMP myotome development
GO:0061197 IMP fungiform papilla morphogenesis
GO:0061551 IMP trigeminal ganglion development
GO:0072075 IMP metanephric mesenchyme development
GO:0072095 IMP regulation of branch elongation involved in ureteric bud branching
GO:0072107 IMP positive regulation of ureteric bud formation
GO:0090190 IMP positive regulation of branching involved in ureteric bud morphogenesis
GO:0098528 IMP skeletal muscle fiber differentiation
GO:1902725 IMP negative regulation of satellite cell differentiation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000004695 six4a sine oculis homeobox homolog 4a protein_coding Danio_rerio
ENSDARG00000031983 six4b sine oculis homeobox homolog 4b protein_coding Danio_rerio
ENSG00000100625 SIX4 SIX homeobox 4 protein_coding Homo_sapiens

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