C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: polycystic kidney disease 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000034462 Pkd2 10090 + 5:104459450-104505819 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000086831 Pkd2-001 104459450-104505819 protein_coding
  ENSMUST00000130931 Pkd2-003 104459570-104490320 processed_transcript
  ENSMUST00000133540 Pkd2-004 104492771-104501349 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000086831ENSMUST00000130931ENSMUST00000133540
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000086831 18.951±6.86 7.283±0.62 31.795±3.69 10.072±3.39 7.430±1.92 8.580±2.06 6.622±0.19 38.592±1.06 2.918±0.51 28.685±1.58 2.716±0.43 14.415±2.71 6.031±1.54 3.963±1.20
ENSMUST00000130931 N/A 6.375±2.24 N/A N/A 4.679±0.06 6.265±0.94 N/A N/A N/A N/A N/A 9.694±4.57 N/A N/A
ENSMUST00000133540 2.277±0.57 3.714±0.00 N/A 2.984±0.91 1.863±0.21 2.933±0.00 0.862±0.10 N/A 0.481±0.26 N/A 0.250±0.00 5.388±0.67 0.650±0.21 0.784±0.04

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000BK CIL_0000BK_0002 CGP 5:104435118-104505819

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001658 IEA branching involved in ureteric bud morphogenesis
GO:0001822 IMP kidney development
GO:0001889 IGI liver development
GO:0001892 IMP embryonic placenta development
GO:0001947 IEA heart looping
GO:0002133 IDA polycystin complex
GO:0003127 IMP detection of nodal flow
GO:0005102 IPI receptor binding
GO:0005244 IEA voltage-gated ion channel activity
GO:0005245 IEA voltage-gated calcium channel activity
GO:0005248 IEA voltage-gated sodium channel activity
GO:0005262 TAS calcium channel activity
GO:0005267 IDA potassium channel activity
GO:0005509 IDA calcium ion binding
GO:0005515 IPI protein binding
GO:0005737 IDA cytoplasm
GO:0005783 TAS endoplasmic reticulum
GO:0005789 IEA endoplasmic reticulum membrane
GO:0005886 IDA plasma membrane
GO:0005887 IEA integral component of plasma membrane
GO:0005911 IDA cell-cell junction
GO:0005929 IDA cilium
GO:0006816 IMP calcium ion transport
GO:0006874 IMP cellular calcium ion homeostasis
GO:0007050 IDA cell cycle arrest
GO:0007204 IEA positive regulation of cytosolic calcium ion concentration
GO:0007259 IDA JAK-STAT cascade
GO:0007368 IMP determination of left/right symmetry
GO:0007507 IMP heart development
GO:0008092 IEA cytoskeletal protein binding
GO:0009925 IEA basal plasma membrane
GO:0010628 IMP positive regulation of gene expression
GO:0015267 IMP channel activity
GO:0021510 IEA spinal cord development
GO:0021915 IEA neural tube development
GO:0022843 IEA voltage-gated cation channel activity
GO:0030027 IEA lamellipodium
GO:0030814 IMP regulation of cAMP metabolic process
GO:0031512 IDA motile primary cilium
GO:0031513 IDA nonmotile primary cilium
GO:0031587 IEA positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0031659 IEA positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
GO:0031941 IEA filamentous actin
GO:0035502 IEA metanephric part of ureteric bud development
GO:0035725 IEA sodium ion transmembrane transport
GO:0035904 IEA aorta development
GO:0036064 IDA ciliary basal body
GO:0042127 IEA regulation of cell proliferation
GO:0042802 IPI identical protein binding
GO:0042803 IEA protein homodimerization activity
GO:0042805 IEA actinin binding
GO:0042994 IEA cytoplasmic sequestering of transcription factor
GO:0043398 IEA HLH domain binding
GO:0044325 IEA ion channel binding
GO:0045180 IDA basal cortex
GO:0045429 IMP positive regulation of nitric oxide biosynthetic process
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0048763 IEA calcium-induced calcium release activity
GO:0050982 IMP detection of mechanical stimulus
GO:0051117 IPI ATPase binding
GO:0051209 IMP release of sequestered calcium ion into cytosol
GO:0051219 IEA phosphoprotein binding
GO:0051371 IEA muscle alpha-actinin binding
GO:0051393 IEA alpha-actinin binding
GO:0060315 IDA negative regulation of ryanodine-sensitive calcium-release channel activity
GO:0060674 IMP placenta blood vessel development
GO:0061333 IMP renal tubule morphogenesis
GO:0061441 IEA renal artery morphogenesis
GO:0070062 IEA extracellular vesicular exosome
GO:0070588 IEA calcium ion transmembrane transport
GO:0071158 IEA positive regulation of cell cycle arrest
GO:0071458 IEA integral component of cytoplasmic side of endoplasmic reticulum membrane
GO:0071464 IEA cellular response to hydrostatic pressure
GO:0071470 IEA cellular response to osmotic stress
GO:0071498 IMP cellular response to fluid shear stress
GO:0071556 IEA integral component of lumenal side of endoplasmic reticulum membrane
GO:0071805 IDA potassium ion transmembrane transport
GO:0071910 IEA determination of liver left/right asymmetry
GO:0072001 IGI renal system development
GO:0072075 IEA metanephric mesenchyme development
GO:0072164 IEA mesonephric tubule development
GO:0072177 IEA mesonephric duct development
GO:0072208 IEA metanephric smooth muscle tissue development
GO:0072214 IEA metanephric cortex development
GO:0072218 IEA metanephric ascending thin limb development
GO:0072219 IEA metanephric cortical collecting duct development
GO:0072235 IEA metanephric distal tubule development
GO:0072284 IEA metanephric S-shaped body morphogenesis
GO:0072686 IDA mitotic spindle
GO:0090279 IEA regulation of calcium ion import
GO:2000134 IEA negative regulation of G1/S transition of mitotic cell cycle

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000014098 pkd2 polycystic kidney disease 2 protein_coding Danio_rerio
ENSG00000118762 PKD2 polycystic kidney disease 2 (autosomal dominant) protein_coding Homo_sapiens

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