C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: pyruvate dehydrogenase kinase, isoenzyme 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000035232 Pdk3 10090 - X:93764607-93832201 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000045748 Pdk3-001 93764607-93832201 protein_coding
  ENSMUST00000134502 Pdk3-002 93782150-93789325 processed_transcript
  ENSMUST00000154717 Pdk3-003 93765096-93769120 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000045748
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000045748 8.251±3.79 9.583±4.76 11.828±0.90 6.279±1.47 6.498±1.99 11.275±1.17 1.812±0.09 14.597±2.48 4.826±5.25 9.891±0.78 0.322±0.14 16.309±6.43 6.245±1.07 6.287±1.06

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008NE CIL_0008NE_0002 VISTA X:93196691-93798662
CIL_00084H CIL_00084H_0002 VISTA X:93277817-93878339
CIL_00007Q CIL_00007Q_0003 CGP X:93654863-93832201

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004672 IEA protein kinase activity
GO:0004674 ISS protein serine/threonine kinase activity
GO:0004740 ISS pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0005515 IEA protein binding
GO:0005524 IEA ATP binding
GO:0005739 IDA mitochondrion
GO:0006006 IEA glucose metabolic process
GO:0010510 ISS regulation of acetyl-CoA biosynthetic process from pyruvate
GO:0010906 ISS regulation of glucose metabolic process
GO:0018105 ISS peptidyl-serine phosphorylation
GO:0035357 ISS peroxisome proliferator activated receptor signaling pathway
GO:0071333 ISS cellular response to glucose stimulus
GO:0071398 ISS cellular response to fatty acid
GO:0097411 ISS hypoxia-inducible factor-1alpha signaling pathway
GO:2000377 ISS regulation of reactive oxygen species metabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000014527 pdk3a pyruvate dehydrogenase kinase, isozyme 3a protein_coding Danio_rerio
ENSDARG00000060460 pdk3b pyruvate dehydrogenase kinase, isozyme 3b protein_coding Danio_rerio
ENSG00000067992 PDK3 pyruvate dehydrogenase kinase, isozyme 3 protein_coding Homo_sapiens

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