C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: methyl-CpG binding domain protein 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000035478 Mbd3 10090 - 10:80392539-80399550 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000092295 Mbd3-001 80392539-80399550 protein_coding
  ENSMUST00000105347 Mbd3-006 80392982-80395719 protein_coding
  ENSMUST00000105348 Mbd3-003 80392839-80399422 protein_coding
  ENSMUST00000105349 Mbd3-002 80392539-80399550 protein_coding
  ENSMUST00000125618 Mbd3-005 80393895-80395326 processed_transcript
  ENSMUST00000142997 Mbd3-004 80392539-80395170 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000092295ENSMUST00000105347ENSMUST00000105349ENSMUST00000125618ENSMUST00000142997
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000092295 10.633±1.74 16.496±3.16 9.671±2.98 14.138±1.42 11.965±0.67 8.433±2.12 7.241±1.55 10.455±2.73 9.399±3.16 8.391±1.43 20.554±4.56 13.553±3.58 11.026±2.70 10.365±1.79
ENSMUST00000105347 N/A N/A N/A 38.669±25.46 2.482±0.00 N/A 8.272±0.51 N/A 15.675±1.64 N/A N/A 30.837±13.55 35.552±8.70 30.796±13.24
ENSMUST00000105349 38.700±13.12 26.560±7.12 25.048±6.69 60.361±8.24 28.698±10.44 22.852±3.23 17.584±3.63 39.061±3.91 23.421±11.02 24.846±8.07 23.181±4.66 34.915±11.75 28.075±8.44 33.949±4.47
ENSMUST00000125618 N/A N/A N/A 66.780±0.00 N/A N/A N/A N/A N/A N/A N/A 83.535±0.00 94.760±54.41 68.686±0.00
ENSMUST00000142997 14.935±3.07 18.535±1.70 10.948±2.21 27.443±5.37 15.680±6.56 17.076±1.78 7.384±1.73 11.967±1.35 9.558±3.24 15.048±0.42 9.198±0.00 30.603±8.30 21.782±12.90 7.656±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003YO CIL_0003YO_0002 CGP 10:80380355-80399550
CIL_0003Z8 CIL_0003Z8_0002 CGP 10:80392539-80406830

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000785 IDA chromatin
GO:0000790 IEA nuclear chromatin
GO:0000792 IDA heterochromatin
GO:0000978 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980 IEA RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001701 IMP in utero embryonic development
GO:0003677 IDA DNA binding
GO:0003682 IDA chromatin binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0006346 IDA methylation-dependent chromatin silencing
GO:0006351 IEA transcription, DNA-templated
GO:0008327 ISS methyl-CpG binding
GO:0009888 IMP tissue development
GO:0016573 IMP histone acetylation
GO:0016581 IPI NuRD complex
GO:0031492 IEA nucleosomal DNA binding
GO:0043044 IEA ATP-dependent chromatin remodeling
GO:0043234 IDA protein complex

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000042029 mbd3b methyl-CpG binding domain protein 3b protein_coding Danio_rerio
ENSDARG00000061774 mbd3a methyl-CpG binding domain protein 3a protein_coding Danio_rerio
ENSG00000071655 MBD3 methyl-CpG binding domain protein 3 protein_coding Homo_sapiens

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