C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: ATP-binding cassette, sub-family A (ABC1), member 7
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000035722 Abca7 10090 + 10:79996494-80015572 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000043866 Abca7-201 79997615-80015568 protein_coding
  ENSMUST00000132517 Abca7-001 79996494-80015572 protein_coding
  ENSMUST00000171637 Abca7-202 79997576-80015553 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000043866ENSMUST00000132517ENSMUST00000171637
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000043866 N/A 3.965±1.12 N/A N/A N/A N/A N/A N/A 0.233±0.06 N/A N/A 3.197±0.90 1.268±0.58 0.042±0.00
ENSMUST00000132517 3.361±0.59 2.911±0.62 1.498±0.46 1.763±0.00 5.423±2.17 8.563±2.90 1.667±0.48 2.266±0.72 2.445±2.42 4.820±1.85 1.605±0.19 2.757±1.11 1.483±0.54 0.611±0.04
ENSMUST00000171637 2.725±0.57 4.397±1.79 N/A 1.314±0.59 3.598±0.44 4.747±1.67 0.777±0.12 1.060±0.15 1.530±1.20 5.218±0.56 0.866±0.25 3.042±1.02 2.065±1.10 0.273±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008XG CIL_0008XG_0002 VISTA 10:79539861-80142369
CIL_0000I2 CIL_0000I2_0002 CGP 10:79988584-80015572
CIL_0000HU CIL_0000HU_0002 CGP 10:79996494-80031472

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001891 IDA phagocytic cup
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005548 IDA phospholipid transporter activity
GO:0005622 IDA intracellular
GO:0005737 IEA cytoplasm
GO:0005768 IEA endosome
GO:0005794 IEA Golgi apparatus
GO:0005886 ISS plasma membrane
GO:0006200 IEA ATP catabolic process
GO:0006909 IEA phagocytosis
GO:0007613 IMP memory
GO:0009986 IDA cell surface
GO:0010875 IDA positive regulation of cholesterol efflux
GO:0016021 IEA integral component of membrane
GO:0016324 IDA apical plasma membrane
GO:0016887 IEA ATPase activity
GO:0017121 ISS phospholipid scrambling
GO:0018149 IDA peptide cross-linking
GO:0032587 IDA ruffle membrane
GO:0032780 ISS negative regulation of ATPase activity
GO:0032781 ISS positive regulation of ATPase activity
GO:0033344 ISS cholesterol efflux
GO:0033700 IDA phospholipid efflux
GO:0034188 IDA apolipoprotein A-I receptor activity
GO:0034380 ISS high-density lipoprotein particle assembly
GO:0034504 IDA protein localization to nucleus
GO:0038027 IDA apolipoprotein A-I-mediated signaling pathway
GO:0042985 IDA negative regulation of amyloid precursor protein biosynthetic process
GO:0050766 IMP positive regulation of phagocytosis
GO:0070374 IMP positive regulation of ERK1 and ERK2 cascade
GO:1900223 IMP positive regulation of beta-amyloid clearance
GO:1901076 IMP positive regulation of engulfment of apoptotic cell
GO:1902430 IDA negative regulation of beta-amyloid formation
GO:1902995 IDA positive regulation of phospholipid efflux

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000074221 ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 protein_coding Danio_rerio
ENSG00000064687 ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 protein_coding Homo_sapiens

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