C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: ectonucleotide pyrophosphatase/phosphodiesterase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000037370 Enpp1 10090 - 10:24637914-24712159 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000039882 Enpp1-003 24641435-24712159 nonsense_mediated_decay
  ENSMUST00000105520 Enpp1-001 24637914-24712158 protein_coding
  ENSMUST00000135846 Enpp1-002 24641806-24711991 protein_coding
  ENSMUST00000142974 Enpp1-005 24668486-24674258 retained_intron
  ENSMUST00000150570 Enpp1-004 24647771-24711997 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000039882ENSMUST00000105520ENSMUST00000135846ENSMUST00000150570
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000039882 0.543±0.38 0.154±0.00 2.342±0.26 0.150±0.06 0.620±0.23 1.336±0.32 0.333±0.02 2.099±0.67 1.276±0.85 0.796±0.18 0.268±0.07 1.212±0.70 0.661±0.33 0.207±0.11
ENSMUST00000105520 1.948±0.49 0.228±0.16 2.951±1.39 0.267±0.13 0.765±0.30 1.823±0.58 0.480±0.20 3.270±0.51 0.929±0.69 0.280±0.00 0.250±0.08 2.290±0.83 0.330±0.15 0.119±0.04
ENSMUST00000135846 0.518±0.39 0.287±0.09 N/A 0.307±0.00 0.707±0.30 1.780±0.53 0.600±0.11 1.249±0.00 0.837±0.62 0.764±0.14 0.134±0.00 1.297±0.17 0.466±0.21 0.140±0.03
ENSMUST00000150570 N/A 0.180±0.04 N/A 0.227±0.00 N/A 1.997±0.37 N/A N/A 1.815±0.00 N/A 0.175±0.00 1.779±0.70 0.930±0.38 0.311±0.05

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00097U CIL_00097U_0002 VISTA 10:24193263-24794942

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003676 IEA nucleic acid binding
GO:0003824 IEA catalytic activity
GO:0004528 IDA phosphodiesterase I activity
GO:0004551 IEA nucleotide diphosphatase activity
GO:0005044 IEA scavenger receptor activity
GO:0005158 IEA insulin receptor binding
GO:0005509 IDA calcium ion binding
GO:0005515 IEA protein binding
GO:0005524 IEA ATP binding
GO:0005615 IEA extracellular space
GO:0005765 IEA lysosomal membrane
GO:0005886 ISO plasma membrane
GO:0005887 IDA integral component of plasma membrane
GO:0006091 IEA generation of precursor metabolites and energy
GO:0006200 IDA ATP catabolic process
GO:0006796 IEA phosphate-containing compound metabolic process
GO:0006898 IEA receptor-mediated endocytosis
GO:0006955 IEA immune response
GO:0008152 IEA metabolic process
GO:0008270 IDA zinc ion binding
GO:0009143 IEA nucleoside triphosphate catabolic process
GO:0009986 IEA cell surface
GO:0016021 IDA integral component of membrane
GO:0030247 IEA polysaccharide binding
GO:0030279 IMP negative regulation of ossification
GO:0030308 IEA negative regulation of cell growth
GO:0030505 IEA inorganic diphosphate transport
GO:0030643 IEA cellular phosphate ion homeostasis
GO:0030730 IEA sequestering of triglyceride
GO:0031214 IEA biomineral tissue development
GO:0031953 IEA negative regulation of protein autophosphorylation
GO:0032869 IEA cellular response to insulin stimulus
GO:0035529 IEA NADH pyrophosphatase activity
GO:0042803 IEA protein homodimerization activity
GO:0045599 IEA negative regulation of fat cell differentiation
GO:0045719 IEA negative regulation of glycogen biosynthetic process
GO:0046325 IEA negative regulation of glucose import
GO:0046627 IEA negative regulation of insulin receptor signaling pathway
GO:0046849 IMP bone remodeling
GO:0046872 IEA metal ion binding
GO:0047429 IEA nucleoside-triphosphate diphosphatase activity
GO:0050427 IEA 3'-phosphoadenosine 5'-phosphosulfate metabolic process
GO:0090305 IEA nucleic acid phosphodiester bond hydrolysis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000005789 enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 protein_coding Danio_rerio
ENSG00000197594 ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 protein_coding Homo_sapiens

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