C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: myeloid cell leukemia sequence 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000038612 Mcl1 10090 + 3:95658721-95663176 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000037947 Mcl1-201 95658721-95663176 protein_coding
  ENSMUST00000178686 Mcl1-202 95658857-95660823 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000037947ENSMUST00000178686
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000037947 24.539±2.68 47.958±7.89 49.793±7.73 18.596±13.69 38.881±11.09 93.126±8.72 24.907±3.31 21.023±1.93 26.089±10.73 49.012±1.95 32.235±9.66 40.928±4.30 28.515±9.77 10.350±0.69
ENSMUST00000178686 18.553±3.74 85.894±21.10 N/A 11.302±0.00 76.441±6.58 69.747±18.20 N/A 11.525±3.36 11.300±7.56 42.785±17.81 N/A 47.432±22.06 48.200±28.27 14.470±5.14

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003OD CIL_0003OD_0003 CGP 3:95624980-95663176

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005739 IDA mitochondrion
GO:0005741 IBA mitochondrial outer membrane
GO:0005759 IDA mitochondrial matrix
GO:0005829 IDA cytosol
GO:0007275 IEA multicellular organismal development
GO:0008630 IDA intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008637 IDA apoptotic mitochondrial changes
GO:0016020 IDA membrane
GO:0016021 IEA integral component of membrane
GO:0030154 IEA cell differentiation
GO:0034097 ISO response to cytokine
GO:0042803 IBA protein homodimerization activity
GO:0043066 IMP negative regulation of apoptotic process
GO:0046982 IBA protein heterodimerization activity
GO:0051434 IPI BH3 domain binding
GO:0097136 IEA Bcl-2 family protein complex
GO:0097192 IMP extrinsic apoptotic signaling pathway in absence of ligand
GO:1903378 IMP positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:2000811 IEA negative regulation of anoikis
GO:2001020 IEA regulation of response to DNA damage stimulus
GO:2001240 IEA negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001243 IBA negative regulation of intrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000008363 mcl1b myeloid cell leukemia sequence 1b protein_coding Danio_rerio
ENSDARG00000009779 mcl1a myeloid cell leukemia sequence 1a protein_coding Danio_rerio
ENSG00000143384 MCL1 myeloid cell leukemia 1 protein_coding Homo_sapiens

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